稳定性冠心病患者血清Perilipin5水平及与心功能的相关性分析  

Levels of serum Perilipin5 in patients with stable coronary artery disease and their correlation with cardiac function

作　　者：左庆娟 和丽丽[1] 马赛[1] 张国瑞[2] 郭艺芳[1] Zuo Qingjuan;He Lili;Ma Sai;Zhang Guorui;Guo Yifang(Department of Geriatric Cardiology,Hebei General Hospital,Shijiazhuang 050051,China;Department of Cardiology,The Third Hospital of Shijiazhuang,Shijiazhuang 050000,China)

机构地区：[1]河北省人民医院老年心血管内科,石家庄050051 [2]石家庄市第三医院心内科,050000

出　　处：《中国心血管杂志》2024年第1期34-39,共6页Chinese Journal of Cardiovascular Medicine

基　　金：河北省医学科学研究课题计划(20200734);2022年政府资助临床医学优秀人才项目。

摘　　要：目的分析Perilipin5(Plin5)在稳定性冠心病(SCAD)患者血清中的表达水平,并探讨其与患者心功能的相关性。方法病例对照研究。选取2020年11月至2021年6月于河北省人民医院住院治疗的183例SCAD患者作为病例组,根据是否存在心力衰竭(HF)分为SCAD组(62例)和SCAD+HF组(121例)。选取同期就诊的57例非冠心病患者作为对照组。对所有纳入的患者进行临床资料的采集,并检测血清N末端B型利钠肽原(NT-proBNP)和检查超声心动图。Pearson相关分析评估Plin5与心功能的相关性。结果121例合并HF的SCAD患者中,58例为射血分数保留的HF,32例为射血分数中间值HF(HFmrEF),31例为射血分数降低的HF(HFrEF)。对照组血清Plin5水平明显高于SCAD组和SCAD+HF组,差异有统计学意义(H=28.156,P<0.001)。Pearson相关分析结果显示,血清Plin5水平与左心室射血分数呈正相关,与左心房内径、左心室收缩末内径、左心室舒张末内径和NT-proBNP呈负相关(均为P<0.01)。多元logistic回归分析显示,Plin5是SCAD患者发生HFmrEF和HFrEF的负向影响因素(均为P<0.05)。结论SCAD患者血清Plin5水平显著降低是其发生HFmrEF和HFrEF的负向影响因素。Objective To analyze the expression levels of serum Perilipin5(Plin5)in patients with stable coronary artery disease(SCAD)and explore their correlation with cardiac function.Methods This was a case-control study.Patients were selected from those hospitalized in Hebei General Hospital from November 2020 to June 2021,including 57 cases in the control group and 183 cases in the SCAD group.SCAD patients were divided into two groups based on the occurrence of heart failure(HF),namely SCAD group(n=62)and SCAD+HF group(n=121).Clinical data of all patients were collected,the serum level of N-terminal pro-B-type natriuretic peptide(NT-proBNP)was detected,and ultrasonic cardiography was performed.The correlation of serum Plin5 level with cardiac function was analyzed by Pearson correlation analysis.Results The SCAD+HF group was subsequently categorized into heart failure with preserved ejection fraction(n=58),heart failure with midrange ejection fraction(HFmrEF)(n=32),and heart failure with reduced ejection fraction(HFrEF)(n=31).The serum Plin5 level in the control group was the highest,followed by those in the SCAD group and SCAD+HF group(H=28.156,P<0.001).Correlation analysis showed that serum Plin5 level was positively correlated with left ventricular ejection fraction,and negatively correlated with left atrial diameter,left ventricular end-systolic diameter,left ventricular enddiastolic diameter,and NT-proBNP level in SCAD patients(all P<0.01).Multivariate logistic regression analysis showed that Plin5 was a negative factor affecting the occurrence of HFmrEF and HFrEF(both P<0.05).Conclusions The serum level of Plin5 in SCAD patients is significantly reduced and serves as a negative influencing factor for the occurrence of HFmrEF and HFrEF.

关 键 词：稳定性冠心病 Perilipin5 心力衰竭 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]