泛素蛋白酶体在糖尿病肾脏疾病足细胞损伤中的作用研究进展  

Research advances on the role of ubiquitin proteasome in podocyte injury of diabetic kidney disease

作　　者：王瑾[1] 戴文玲[1] 刘吉华[1] Wang Jin;Dai Wen-ling;Liu Ji-hua(Jiangsu Provincial Key Laboratory of TCM Evaluations&Translational Researches,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学江苏省中药评价与转化重点实验室,南京211198

出　　处：《临床肾脏病杂志》2024年第2期155-159,共5页Journal Of Clinical Nephrology

基　　金：中国药科大学“双一流”建设项目(CPU2018GY32)。

摘　　要：糖尿病肾脏疾病是长期高血糖引起的肾脏结构功能异常损伤疾病。糖尿病肾脏疾病中足细胞损伤是肾脏炎症、肾小球过滤屏障损伤和肾脏纤维化变化的主要原因。泛素蛋白酶体系统是细胞内蛋白清除的主要途径,近年来研究发现其在糖尿病肾脏疾病足细胞损伤中发挥重要作用。高糖相关损伤因素引起足细胞蛋白酶体功能异常、泛素连接酶表达水平改变、去泛素酶活动增加,进而造成足细胞内损伤性蛋白积累或者保护性蛋白异常降解,促进足细胞损伤。现对糖尿病肾脏疾病中足细胞损伤和泛素蛋白酶体参与的损伤机制进行综述。Diabetic kidney disease(DKD)is a disease of abnormal renal structure and function due to long-term hyperglycemia.Podocyte injury is a major cause of renal inflammation,glomerular filtration barrier injury and renal fibrosis.Ubiquitin proteasome system is involved in intracellular protein clearance.Recent studies have confirmed that it plays an important role in podocyte injury of DKD.High glucose-related injury factors cause an abnormal function of podocyte proteasome,an altered expression level of ubiquitin ligase and an enhancement of deubiquitinating enzyme activity.As a result,an accumulation of injurious protein or an abnormal degradation of protective protein in podocyte may accentuate podocyte injury.This review focused upon the mechanisms of podocyte injury and ubiquitin proteasome involvement in DKD.

关 键 词：糖尿病肾脏疾病 足细胞 泛素蛋白酶体系统 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]