基于代谢组学探讨阿司匹林对小鼠急性炎症的干预作用  

Metabolome analysis of effect of aspirin on cute inflammation in mice

作　　者：赵淑锐 王耀楠[1] 吴英婷[1] 郑美青[1] Zhao Shurui;Wang Yaonan;Wu Yingting;Zheng Meiqing(School of Pharmaceutical Sciences,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学药学院,北京100069

出　　处：《分析仪器》2024年第1期44-48,共5页Analytical Instrumentation

摘　　要：采用UPLC-Q-TOF/MS技术,通过代谢组学的研究方法,探讨阿司匹林在二甲苯诱导的小鼠急性耳肿胀实验中血浆代谢物的差异及影响的代谢途径。结果发现阿司匹林逆转了9种急性炎症的血浆代谢物标志物。主要通过调节血浆中抗坏血酸和醛酸代谢,甘油磷脂代谢,葡萄糖醛酸酯的相互转化代谢,花生四烯酸代谢来影响机体的代谢。UPLC-Q-TOF/MS technology was used to explore the differences in plasma metabolites and the metabolic pathways affected by aspirin in xylene-induced acute ear swelling in mice through a metabolomics method.The results showed that aspirin reversed nine plasma metabolite markers of acute inflammation.Aspirin mainly affected the metabolism of the body by regulating the ascorbate and aldarate metabolism,pentose and glucuronate interconversions,glycerophospholipid metabolism,arachidonic acid metabolism.

关 键 词：阿司匹林 UPLC-Q-TOF/MS 代谢组学 二甲苯 炎症 

分 类 号：R965[医药卫生—药理学]