维生素E对围绝经期和绝经后妇女健康的影响  

Effects of Vitamin E on the Health of Perimenopausal and Postmenopausal Women

作　　者：刘湘 敖凯 高艺苇 吴琼 穆玉兰 LIU Xiang;AO Kai;GAO Yi-wei;WU Qiong;MU Yu-lan(The Second Clinical College of Shandong University of Traditional Chinese Medicine,Jinan 250013,China;Department of Gynecology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Ji′nan 250021,China)

机构地区：[1]山东中医药大学第二临床医学院,济南250013 [2]山东第一医科大学附属省立医院妇科

出　　处：《国际妇产科学杂志》2024年第1期93-98,共6页Journal of International Obstetrics and Gynecology

基　　金：山东省自然科学基金面上项目(ZR2020MH062)。

摘　　要：随着年龄的增长,卵巢功能由旺盛期到逐渐减退,直至衰竭,女性也将从生殖期逐渐进入老年期。这不仅会对月经周期和生育能力有影响,还会伴随着一系列身体和心理上的变化,严重时会影响生活和工作。研究发现卵巢卵泡的发育以及绝经前后出现的泌尿生殖功能异常、骨质疏松、神经认知功能障碍及心血管病变等疾病的发生发展可能与氧化应激反应有着密不可分的关系。维生素E具有抗氧化特性和稳定细胞的能力,已经被证实可在代谢综合征、骨质疏松、心脑血管、神经系统等疾病的预防和治疗方面发挥着重要作用,并且发现维生素E在一定程度上还具有模拟雌激素的作用。因此,补充维生素E对围绝经期和绝经后妇女的健康具有潜在的益处。综述维生素E对围绝经期卵巢卵泡发育、雌激素的影响和绝经综合征的预防和治疗作用,为维生素E作为改善围绝经期和绝经后妇女身心健康的辅助或替代治疗方案提供参考依据。With the increase of age,ovarian function gradually declines from the flourishing period,until the failure,women will gradually enter the old age from the reproductive period.This will not only affect the menstrual cycle and fertility,but also be accompanied by a series of physical and psychological changes,which can significantly impact daily life and work.Studies have found that the development of ovarian follicles and the occurrence and development of urogenital dysfunction,osteoporosis,neurocognitive dysfunction,cardiovascular diseases and other diseases before and after menopause may be closely related to oxidative stress.Vitamin E has antioxidant properties and the ability to stabilize cells,and has been proven to play an important role in the prevention and treatment of metabolic syndrome,osteoporosis,cardiovascular and cerebrovascular diseases,neurological disorder and other diseases.Moreover,it has been found that vitamin E also has estrogen-like effects to a certain extent.Therefore,vitamin E supplementation has potential benefits for the health of perimenopausal and postmenopausal women.This article comprehensively expounds the effects of vitamin E on ovarian follicle development and estrogen during perimenopause,and the preventive and therapeutic roles in menopause syndrome,so as to provide reference for considering vitamin E as an adjuvant or alternative therapy to improve the physical and mental health of perimenopause and postmenopausal women.

关 键 词：维生素E 绝经综合征 围绝经期 绝经后期 抗氧化剂 

分 类 号：R173[医药卫生—妇幼卫生保健]