普罗帕酮诱发Brugada样心电图改变一例  

Brugada-like Electrocardiographic Changes Induced by Propafenone:a Case Report

作　　者：张羽[1] 辛宪奕 周岩[1] ZHANG Yu;XIN Xianyi;ZHOU Yan(Department of Pediatric Cardiology,The First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院小儿心血管科,长春130021

出　　处：《中国循环杂志》2024年第2期194-198,共5页Chinese Circulation Journal

摘　　要：Brugada综合征主要在成年时期出现症状,且主要在休息或睡眠中发生猝死,儿童时期并不常见,尤其以心房扑动为首发表现的相关报道鲜见。本文报道一例以心房扑动为首发表现的13岁患儿,无基础心脏疾病,在接受普罗帕酮治疗的过程中诱发出Brugada样心电图改变,基因检测发现可疑变异基因SCN5A,变异位点为c.2834A>G(p.D945G)。希望通过本病例的诊断、治疗及相关文献回顾,提高临床医师对Brugada综合征的诱发因素以及其可合并多种心律失常的认识,加强在应用抗心律失常药物时的心电监测,并对此类高危人群进行指导和密切随访,从而避免不良事件的发生。Brugada syndrome presents mainly in adulthood,and sudden death occurs mainly at rest or during sleep.It is uncommon in childhood,especially with atrial flutter as the first manifestation.In this article,we report a case of a 13-year-old child with atrial flutter as the first manifestation,without underlying cardiac disease,who developed Brugada-like electrocardiographic changes during the treatment of propafenone,and genetic testing revealed the suspected mutant genes SCN5A(c.2834A>G[p.D945G]).Present case and related literature review might improve the awareness of clinicians on the inducing factors of Brugada syndrome and related a variety of cardiac arrhythmias,the importance of electrocardiogram monitoring during the application of antiarrhythmic drugs,and provide guidance and close follow-up strategies to this high-risk group,so as to avoid the occurrence of adverse events in these patients.

关 键 词：BRUGADA综合征 普罗帕酮 心房扑动 

分 类 号：R541.4[医药卫生—心血管疾病]