血清双调蛋白、间皮素对乳腺癌辅助诊断的价值  

Serum amphiregulin and mesothelin in auxiliary diagnosis of breast cancer

作　　者：刘泊含 刘鷖雯[2] 何怡青[2] 卢仁泉 杜艳[2] 张国良[2] 郭倩[2] 高锋[1] 杨翠霞[1] LIU Bohan;LIU Yiwen;HE Yiqing;LU Renquan;DU Yan;ZHANG Guoliang;GUO Qian;GAO Feng;YANG Cuixia(Department of Clinical Laboratory,the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200233,China;Central Laboratory,the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200233,China;Department of Clinical Laboratory,Cancer Hospital of Fudan University,Shanghai 200032,China)

机构地区：[1]上海交通大学附属第六人民医院检验科,上海200233 [2]上海交通大学附属第六人民医院中心实验室,上海200233 [3]复旦大学附属肿瘤医院检验科,上海200032

出　　处：《检验医学》2024年第1期26-30,共5页Laboratory Medicine

基　　金：国家自然科学基金项目(82273462);国家自然科学基金项目(81974445)。

摘　　要：目的 探讨血清双调蛋白(AREG)和间皮素(MSLN)水平在乳腺癌辅助诊断中的价值。方法选取2018年12月—2019年5月就诊于复旦大学附属肿瘤医院的女性乳腺癌患者54例(乳腺癌组)、乳腺良性病变患者38例(良性病变组)和表观健康者35名(健康对照组)。采用酶联免疫吸附试验检测血清AREG和MSLN水平。分析乳腺癌患者血清AREG和MSLN水平与临床病理特征的关系。采用受试者工作特征(ROC)曲线评估AREG、MSLN单独和联合癌胚抗原(CEA)、糖类抗原(CA)15-3检测辅助诊断乳腺癌的效能。结果 与健康对照组比较,乳腺癌组血清AREG、MSLN水平均显著升高(P<0.05)。AREG、MSLN检测诊断乳腺癌的曲线下面积(AUC)分别为0.582、0.637,而血清AREG、MSLN联合CEA、CA15-3检测的AUC为0.757。乳腺癌组血清AREG、MSLN水平与病理类型和淋巴转移有关(P<0.05)。结论 血清AREG、MSLN联合CEA和CA15-3检测可在乳腺癌辅助诊断中具有一定作用。Objective To investigate the roles of serum amphiregulin(AREG)and mesothelin(MSLN)levels in the auxiliary diagnosis of breast cancer.Methods A total of 54 female patients with breast cancer(breast cancer group),38 patients with benign breast lesions(benign lesion group)and 35 apparently healthy subjects(healthy control group)were enrolled from the Cancer Hospital of Fudan University from December 2018 to May 2019.Serum AREG and MSLN levels were determined by enzyme-linked immunosorbent assay.The relationship between serum AREG and MSLN levels and clinicopathological characteristics of breast cancer patients was analyzed.The efficacy of AREG and MSLN alone and in combination with carcinoembryonic antigen(CEA)and carbohydrate antigen(CA)15-3 in the auxiliary diagnosis of breast cancer was evaluated by receiver operating characteristic(ROC)curve.Results Compared with healthy control group,serum AREG and MSLN levels in breast cancer group were increased(P<0.05).The areas under curves(AUC)of AREG and MSLN in the diagnosis of breast cancer were 0.582 and 0.637,respectively,while the AUC of serum AREG and MSLN combined with CEA and CA15-3 was 0.757.Serum AREG and MSLN levels in breast cancer group were related with pathological types and lymphatic metastasis(P<0.05).Conclusions Serum AREG,MSLN combined with CEA and CA15-3 can play a role in the auxiliary diagnosis of breast cancer.

关 键 词：双调蛋白 间皮素 乳腺癌 

分 类 号：R446.1[医药卫生—诊断学]