基于5-HT及其受体的中医药干预消化系统疾病研究进展  

Research Progress of Traditional Chinese Medicine in the Intervention of Digestive System Diseases Based on 5⁃HT and Its Receptor

作　　者：康楠[1] 李家立[1] KANG Nan;LI Jiali(Department of Traditional Chinese Medicine,Affiliated Hospital of Jining Medical University,Shandong Province,Jining 272029,China)

机构地区：[1]济宁医学院附属医院中医科,山东济宁272029

出　　处：《光明中医》2024年第1期190-193,共4页GUANGMING JOURNAL OF CHINESE MEDICINE

基　　金：国家自然科学基金项目(No.81804064);山东省自然科学基金项目(No.ZR2018BH034);山东省中医药科技项目(No.2021Z039);齐鲁卫生与健康杰出青年人才项目(No.鲁卫人字[2020]3号);山东省中医药高层次人才培育项目专项经费资助。

摘　　要：5羟色胺(5-hydroxytryptamine,5-HT)是一种重要的单胺类神经递质,具有广泛的生物学效应。血清和胃肠道中的5-HT含量可占人体5-HT总量的95%以上,血液循环中的5-HT也主要来源于肠道。5-HT在消化系统疾病发生发展中的作用历来受到关注。此文从5-HT特征、5-HT受体以及基于5-HT及其受体探讨中医药对消化系统疾病的干预作用进行了概述,以期进一步为消化系统疾病的防治、临床与基础研究提供新思路。5⁃hydroxytryptamine(5⁃HT)is an important monoamine neurotransmitter and has a wide range of biological effects.In recent years,the role of 5⁃HT in the occurrence and development of digestive system disease has been always in the spotlight.This paper summarized the structural characteristics of 5⁃HT,5⁃HT receptor,its relationship with digestive system disease and the intervention of traditional Chinese medicine on digestive system disease based on 5⁃HT and its receptor,in order to provide new ideas for the prevention and treatment of digestive system disease and clinical and basic research.

关 键 词：5-HT 5-HT受体 消化系统疾病 

分 类 号：R259[医药卫生—中西医结合]