降脂通络软胶囊与冠心宁片联合西药治疗气滞血瘀型慢性稳定型心绞痛临床研究  

Clinical Study on Jiangzhi Tongluo Soft Capsules and Guanxinning Tablets Combined with Western Medicine for Chronic Stable Angina Pectoris of Qi Stagnation and Blood Stasis Type

作　　者：周砚田 王祝英 ZHOU Yantian;WANG Zhuying(Zhuji Hospital of Traditional Chinese Medicine,Zhuji Zhejiang 311800,China)

机构地区：[1]诸暨市中医医院,浙江诸暨311800

出　　处：《新中医》2024年第1期23-28,共6页New Chinese Medicine

摘　　要：目的:观察降脂通络软胶囊与冠心宁片联合西药治疗气滞血瘀型慢性稳定型心绞痛的临床疗效及对心电图指标的影响。方法:将138例气滞血瘀型慢性稳定型心绞痛患者按照随机数字表法分为对照组和研究组各69例。2组均予常规西药治疗,研究组加予降脂通络软胶囊联合冠心宁片口服治疗,2组均治疗8周。治疗前后统计患者的心绞痛发作频率、每次心绞痛发作持续时间,评定中医证候评分;进行24 h动态心电图检查,比较ST段压低次数、ST段压低最大值和ST段压低总时间;测定血清N-末端脑钠肽前体(NT-proBNP)、同型半胱氨酸(Hcy)含量。比较2组临床疗效和不良反应发生率。结果:治疗8周后,研究组总有效率(92.75%)高于对照组(73.91%),差异有统计学意义(P<0.05)。2组心绞痛发作频率均较治疗前降低,心绞痛发作持续时间均较治疗前缩短,差异均有统计学意义(P<0.05)。研究组心绞痛发作频率低于对照组,心绞痛发作持续时间短于对照组,差异均有统计学意义(P<0.05)。2组ST段压低次数、ST段压低最大值均较治疗前减少,ST段压低总时间均较治疗前缩短,差异均有统计学意义(P<0.05)。研究组ST段压低次数少于对照组,ST段压低最大值低于对照组,ST段压低总时间短于对照组,差异均有统计学意义(P<0.05)。2组血清NT-proBNP、Hcy含量均较治疗前下降(P<0.05)。研究组血清NT-proBNP、Hcy含量均低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规西药治疗基础上加予降脂通络软胶囊联合冠心宁片治疗,可有效缓解气滞血瘀型慢性稳定型心绞痛患者的临床症状,改善心脏功能,发挥保护心肌作用,且不增加用药风险。Objective:To observe the clinical effect of the therapy of Jiangzhi Tongluo Soft Capsules and Guanxinning Tablets combined with western medicine on chronic stable angina pectoris of qi stagnation and blood stasis type and its influence on electrocardiogram indexes.Methods:A total of 138 patients with chronic stable angina pectoris of qi stagnation and blood stasis type were divided into the control group and the study group according to random number table method,with 69 patients in each group.The two groups were treated with conventional western medicine,and the study group was additionally treated with Jiangzhi Tongluo Soft Capsules and Guanxinning Tablets orally.Both groups were treated for 8 weeks.Before and after treatment,the frequency of angina pectoris and the duration of each angina pectoris attack were measured,and the traditional Chinese medicine syndrome scores were evaluated;24-hour holter electrocardiogram was performed to compare the times of ST segment depression,the maximum ST segment depression and the total time of ST segment depression;the contents of N-terminal brain natriuretic peptide precursor(NT-proBNP)and homocysteine(Hcy)in serum were determined.The clinical effects and incidence of adverse reactions were compared between the two groups.Results:After 8 weeks of treatment,the total effective rate was 92.75%in the study group,higher than that of 73.91%in the control group,the difference being significant(P<0.05).The frequency of angina pectoris attack in the two groups were decreased when compared with those before treatment,and the duration of angina pectoris attack were shortened when compared with those before treatment,differences being significant(P<0.05).The frequency of angina pectoris attack in the study group was lower than that in the control group,and the duration of angina pectoris attack was shorter than that in the control group,differences being significant(P<0.05).The times of ST segment depression and the maximum ST segment depression in the two groups were decreased when

关 键 词：冠心病 慢性稳定型心绞痛 气滞血瘀证 降脂通络软胶囊 冠心宁片 心电图 

分 类 号：R541.4[医药卫生—心血管疾病]