益气养阴汤联合西药治疗特发性肺纤维化缓解期临床研究  

Clinical Study on Yiqi Yangyin Decoction Combined with Western Medicine for Idiopathic Pulmonary Fibrosis in Remission Stage

作　　者：徐小小 叶新新 李献超[2] 潘锟镭[2] XU Xiaoxiao;YE Xinxin;LI Xianchao;PAN Kunlei(Department of Critical Care Medicine,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou Zhejiang 325400,China;Department of Respiratory and Critical Care Medicine,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou Zhejiang 325400,China)

机构地区：[1]温州市中医院重症医学科,浙江温州325400 [2]温州市中医院呼吸与危重症医学科,浙江温州325400

出　　处：《新中医》2024年第1期56-60,共5页New Chinese Medicine

基　　金：温州市科技计划项目(Y2020877)。

摘　　要：目的:观察益气养阴汤联合西药治疗特发性肺纤维化(IPF)缓解期的临床疗效。方法:采用随机数字表法将66例IPF缓解期患者分为试验组、对照组各33例。对照组给予常规西药治疗,试验组给予益气养阴汤联合西药治疗,2组连续治疗2个月。比较2组治疗前后中医证候积分、高分辨率CT(HRCT)半定量评分、肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、最大呼气峰流速(PEF)、肺总量(TLC)]、动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2)),评估2组临床疗效及不良反应发生情况。结果:试验过程中,试验组剔除2例,完成研究31例;对照组剔除3例,完成研究30例。治疗后,试验组总有效率为90.32%,高于对照组70.00%(P<0.05)。2组治疗后中医证候积分、HRCT半定量评分、PaCO_(2)水平均治疗前降低(P<0.05),PaO_(2)水平均升高(P<0.05);试验组治疗后中医证候积分、HRCT半定量评分、PaCO_(2)水平低于对照组(P<0.05),PaO_(2)水平高于对照组(P<0.05)。2组治疗后FVC、FEV_(1)、PEF、TLC水平均高于治疗前(P<0.05),且试验组治疗后肺功能指标均高于对照组(P<0.05)。试验组、对照组不良反应发生率分别为9.68%、13.33%,2组比较,差异无统计学意义(P>0.05)。结论:益气养阴汤联合西药治疗IPF缓解期疗效确切,能改善患者肺功能,缓解肺纤维化,安全性较高。Objective:To observe the clinical effect of the therapy of Yiqi Yangyin Decoction combined with western medicine on idiopathic pulmonary fibrosis(IPF)in remission stage.Methods:A total of 66 patients with IPF in remission stage were divided into the trial group and the control group according to the random number table method,with 33 cases in each group.The control group was given routine western medicine for treatment,and the trial group was treated with Yiqi Yangyin Decoction combined with western medicine.The two groups were treated for two months.The traditional Chinese medicine(TCM)syndrome scores,the semi-quantitative scores of high resolution CT(HRCT),indexes of lung function,including forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1)),peak expiratory flow(PEF)and total lung capacity(TLC),partial pressure of carbon dioxide(PaCO_(2))in arterial blood,and partial pressure of oxygen(PaO_(2))in arterial blood were compared before and after treatment between the two groups;the clinical effects and incidence of adverse reactions in both groups were evaluated.Results:During the trial,2 cases dropped off in the trial group,and finally 31 cases were included;3 cases dropped off in the control group,and finally 30 cases were included.After treatment,the total effective rate was 90.32%in the trial group,higher than that of 70.00%in the control group(P<0.05).After treatment,the TCM scores,HRCT semi-quantitative scores and PaCO_(2) levels in the two groups were decreased when compared with those before treatment(P<0.05),and the PaO_(2) levels were increased(P<0.05).After treatment,the TCM syndrome score,HRCT semi-quantitative scores and PaCO_(2) level in the trial group were lower than those in the control group(P<0.05),and the PaO_(2) level was higher than that in the control group(P<0.05).After treatment,the levels of FVC,FEV_(1),PEF and TLC in the two groups were higher than those before treatment(P<0.05),and the above levels in the trial group were higher than those in the control group(P<0.

关 键 词：特发性肺纤维化 缓解期 益气养阴汤 肺功能 动脉血二氧化碳分压 动脉血氧分压 

分 类 号：R563.9[医药卫生—呼吸系统]