肺热咳喘方联合常规疗法治疗社区获得性肺炎痰热壅肺证临床研究  

Clinical Study on Feire Kechuan Prescription Combined with Conventional Therapy for Community-Acquired Pneumonia with Phlegm-Heat Obstructing the Lung Syndrome

作　　者：何薇[1] 李慧娇[1] 李国华[1] 王一萍[1] 尤志新 HE Wei;LI Huijiao;LI Guohua;WANG Yiping;YOU Zhixin(Department of Respiration,Shaoxing Hospital of Traditional Chinese Medicine,Shaoxing Zhejiang 312000,China)

机构地区：[1]绍兴市中医院呼吸科,浙江绍兴312000

出　　处：《新中医》2024年第1期61-66,共6页New Chinese Medicine

基　　金：浙江省中医药科技计划项目(2021ZB304)。

摘　　要：目的:观察肺热咳喘方联合常规疗法治疗社区获得性肺炎痰热壅肺证的疗效。方法:选取123例痰热壅肺证社区获得性肺炎患者,按随机数字表法分为对照组60例及联合组63例。对照组采用常规西药治疗,联合组采用肺热咳喘方联合常规西药治疗,2组均治疗2周。观察2组临床疗效、影像学检查结果、不良反应发生情况及临床症状消退时间,比较2组治疗前后中医证候积分、血清C-反应蛋白(CRP)、降钙素原(PCT)、白细胞计数(WBC)水平的变化。结果:治疗后,2组中医证候积分主症、次症、总分均较治疗前下降(P<0.05),联合组中医证候积分主症、次症、总分均低于对照组(P<0.05)。治疗后,联合组退热、咳嗽消退、咳痰消退及肺部啰音消退时间均短于对照组,差异均有统计学意义(P<0.05)。治疗后,2组CRP、PCT、WBC水平均较治疗前下降(P<0.05),联合组上述3项水平均低于对照组(P<0.05)。治疗后,联合组影像学吸收率为95.24%,对照组为81.67%,2组比较,差异有统计学意义(P<0.05)。联合组临床疗效总有效率为95.24%,对照组为81.67%,2组比较,差异有统计学意义(P<0.05)。联合组不良反应发生率为6.35%,对照组不良反应发生率为8.33%,2组比较,差异无统计学意义(P>0.05)。结论:肺热咳喘方联合现代医学治疗社区获得性肺炎痰热壅肺证能明显缓解症状,降低炎症水平,临床疗效显著,且安全性良好。Objective:To observe the curative effect of Feire Kechuan Prescription combined with conventional therapy for community-acquired pneumonia with phlegm-heat obstructing the lung syndrome.Methods:A total of 123 cases of patients with community-acquired pneumonia with phlegmheat obstructing the lung syndrome were selected and divided into the control group and the combination group according to the random number table method,with 60 and 63 cases in each group,respectively.The control group was treated with conventional western medicine treatment,and the combination group was treated with Feire Kechuan Prescription combined with conventional western medicine therapy.Both groups were treated for 2 weeks.Clinical effects,imaging findings,the incidence of adverse reactions,and the remission time of clinical symptoms were observed in the two groups.Traditional Chinese medicine(TCM)syndrome scores and the levels of C-reactive protein(CRP),procalcitonin(PCT),and white blood cell count(WBC)in serum were compared between the two groups before and after treatment.Results:After treatment,the scores of main symptoms and secondary symptoms,and the total scores of TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),the scores of main symptoms and secondary symptoms,and the total scores of TCM syndrome scores in the combination group were lower than those in the control group(P<0.05).After treatment,the remission time of fever,cough,expectoration,and lung rales in the combination group was shorter than that in the control group,differences being significant(P<0.05).After treatment,the levels of CRP,PCT and WBC in the two groups were decreased when compared with those before treatment(P<0.05),and the above three levels in the combination group were lower than those in the control group(P<0.05).After treatment,the imaging absorption rate was 95.24%in the combination group and 81.67%in the control group,the difference being significant(P<0.05).The total clinical effective rate was 95

关 键 词：社区获得性肺炎 痰热壅肺证 肺热咳喘方 炎性因子 

分 类 号：R563.1[医药卫生—呼吸系统]