清肝散结消瘿方联合左甲状腺素钠治疗桥本甲状腺炎临床研究  

Clinical Study on Qinggan Sanjie Xiaoying Prescription Combined with Levothyroxine Sodium for Hashimoto Thyroiditis

作　　者：刘华朋 杨静[2] 王松[1] 褚桂克[1] 薛榜稳 周倩 LIU Huapeng;YANG Jing;WANG Song;CHU Guike;XUE Bangwen;ZHOU Qian(Department of Endocrinology,Nanyang Central Hospital,Nanyang Henan 473000;Department of Children's Respiratory,Nanyang Central Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市中心医院内分泌科,河南南阳473000 [2]南阳市中心医院儿童呼吸科,河南南阳473000

出　　处：《新中医》2024年第1期94-98,共5页New Chinese Medicine

基　　金：南阳市科技计划项目(KJGG154)。

摘　　要：目的:观察清肝散结消瘿方联合左甲状腺素钠治疗桥本甲状腺炎的临床疗效及对患者免疫功能、氧化应激的影响。方法:采用随机数字表法将63例桥本甲状腺炎患者分为对照组31例与观察组32例。对照组予以左甲状腺素钠治疗,观察组予以清肝散结消瘿方联合左甲状腺素钠治疗,2组连续治疗12周。比较2组治疗前后中医证候积分、甲状腺自身抗体、甲状腺功能、免疫功能、氧化应激水平。结果:观察组总有效率93.75%,高于对照组67.74%(P<0.05)。2组治疗后中医证候积分、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、促甲状腺激素(TSH)、CD8^(+)、丙二醛水平均较治疗前降低(P<0.05);游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)、CD3^(+)、CD4^(+)、超氧化物歧化酶、谷胱甘肽过氧化酶活性升高(P<0.05),且观察组治疗后中医证候积分、甲状腺自身抗体、TSH、CD8^(+)、丙二醛水平均低于对照组(P<0.05),FT3、FT4、CD3^(+)、CD4^(+)、超氧化物歧化酶、谷胱甘肽过氧化酶活性水平均高于对照组(P<0.05)。结论:清肝散结消瘿方联合左甲状腺素钠治疗桥本甲状腺炎,能够改善患者甲状腺功能,减少氧化应激反应,提高免疫功能,临床疗效显著。Objective:To observe the clinical effect of the therapy of Qinggan Sanjie Xiaoying Prescription combined with Levothyroxine Sodium on Hashimoto thyroiditis and its influence on immune function and oxidative stress.Methods:A total of 63 patients with Hashimoto thyroiditis were divided into the control group(31 cases)and the observation group(32 cases)by random number table method.The control group was treated with Levothyroxine Sodium,and the observation group was additionally treated with Qinggan Sanjie Xiaoying Prescription combined with Levothyroxine Sodium.Both groups were treated continuously for 12 weeks.Before and after treatment,traditional Chinese medicine(TCM)syndrome scores,thyroid autoantibody,thyroid function,immune function and oxidative stress levels were compared between the two groups.Results:The total effective rate was 93.75%in the observation group,higher than that of 67.74%in the control group(P<0.05).After treatment,the TCM syndrome scores,thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb),thyroid stimulating hormone(TSH),CD8^(+)and malondialdehyde levels in the two groups were all decreased when compared with those before treatment(P<0.05);the activity levels of free triiodothyronine(FT3),serum free thyroxine(FT4),CD3^(+),CD4^(+),superoxide dismutase and glutathione peroxidase were increased when compared with those before treatment(P<0.05).After treatment,the TCM syndrome scores,thyroid autoantibody,TSH,CD8^(+)and malondialdehyde levels in the observation group were lower than those in the control group(P<0.05),and the activity levels of FT3,FT4,CD3^(+),CD4^(+),superoxide dismutase and glutathione peroxidase in the observation group were higher than those in the control group(P<0.05).Conclusion:The therapy of Qinggan Sanjie Xiaoying Prescription combined with Levothyroxine Sodium for Hashimoto thyroiditis can improve the thyroid function,reduce the oxidative stress reaction,enhance the immune function,and has a significant clinical effect.

关 键 词：桥本甲状腺炎 清肝散结消瘿方 左甲状腺素钠 甲状腺功能 免疫功能 氧化应激 

分 类 号：R581.4[医药卫生—内分泌]