Effect of applied electric fields on supralinear dendritic integration of interneuron  

作　　者：樊亚琴 魏熙乐 卢梅丽 伊国胜 Ya-Qin Fan;Xi-Le Wei;Mei-Li Lu;Guo-Sheng Yi(Tianjin Key Laboratory of Process Measurement and Control,School of Electrical and Information Engineering,Tianjin University,Tianjin 300072,China;School of Information Technology Engineering,Tianjin University of Technology and Education,Tianjin 300222,China)

机构地区：[1]Tianjin Key Laboratory of Process Measurement and Control,School of Electrical and Information Engineering,Tianjin University,Tianjin 300072,China [2]School of Information Technology Engineering,Tianjin University of Technology and Education,Tianjin 300222,China

出　　处：《Chinese Physics B》2024年第2期84-95,共12页中国物理B（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(Grant No.62171312);the Tianjin Municipal Education Commission Scientific Research Project,China(Grant No.2020KJ114).

摘　　要：Evidences show that electric fields(EFs)induced by the magnetic stimulation could modulates brain activities by regulating the excitability of GABAergic interneuron.However,it is still unclear how and why the EF-induced polarization affects the interneuron response as the interneuron receives NMDA synaptic inputs.Considering the key role of NMDA receptor-mediated supralinear dendritic integration in neuronal computations,we suppose that the applied EFs could functionally modulate interneurons’response via regulating dendritic integration.At first,we build a simplified multi-dendritic circuit model with inhomogeneous extracellular potentials,which characterizes the relationship among EF-induced spatial polarizations,dendritic integration,and somatic output.By performing model-based singular perturbation analysis,it is found that the equilibrium point of fast subsystem can be used to asymptotically depict the subthreshold input–output(sI/O)relationship of dendritic integration.It predicted that EF-induced strong depolarizations on the distal dendrites reduce the dendritic saturation output by reducing driving force of synaptic input,and it shifts the steep change of sI/O curve left by reducing stimulation threshold of triggering NMDA spike.Also,the EF modulation prefers the global dendritic integration with asymmetric scatter distribution of NMDA synapses.Furthermore,we identify the respective contribution of EF-regulated dendritic integration and EF-induced somatic polarization to an action potential generation and find that they have an antagonistic effect on AP generation due to the varied NMDA spike threshold under EF stimulation.

关 键 词：GABAergic interneuron electrical field supralinear dendritic integration action potential generation 

分 类 号：Q42[生物学—神经生物学]