Defined hydrogels for spinal cord organoids:challenges and potential applications  

作　　者：Wai Hon Chooi Yuewen Wu Shi-Yan Ng 

机构地区：[1]Institute of Molecular and Cell Biology(IMCB),Agency for Science,Technology and Research(A*STAR),Singapore,Singapore [2]Department of Physiology,Yong Loo Lin School of Medicine,National University of Singapore(NUS),Singapore,Singapore

出　　处：《Neural Regeneration Research》2024年第11期2329-2330,共2页中国神经再生研究（英文版）

基　　金：supported by A*STAR Career Development Fund (C210112011);National Medical Research Council (MOH-001248-00)(to WHC);Singapore International Graduate Award (to YW);National Research Foundation (NRFNRFF-2018-003);Biomedical Research Council,A*STAR Research Entities (to SYN)

摘　　要：Organoids of the central nervous system,primarily derived from pluripotent stem cells or neural stem cells,are three-dimensional tissue cultures with self-organizing properties.When exposed to the right combinations of signals,they differentiate into a 3D tissue consisting of complex cytoarchitecture and native cell types,including various neuron subtypes and glial cells.These features closely mimic native tissues,making them invaluable for developmental studies and disease modeling.In recent years,spinal cord organoids(SCOs)have been developed to investigate spinal cord development,injuries,and various neurological disorders.As an integral part of the central nervous system,SCOs play a vital role and serve as a site for studying both neurodevelopment and neurodegenerative diseases.

关 键 词：PROPERTIES INJURIES primarily 

分 类 号：TQ427.26[化学工程] R318[医药卫生—生物医学工程]