Fish-on-Chips:unveiling neural processing of chemicals in small animals through precise fluidic control  

作　　者：Samuel K.H.Sy Ho Ko 

机构地区：[1]Division of Neurology,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,New Territories,Hong Kong Special Administrative Region,China [2]Li Ka Shing Institute of Health Sciences,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,New Territories,Hong Kong Special Administrative Region,China [3]Department of Electrical and Electronic Engineering,Faculty of Engineering,The University of Hong Kong,Pok Fu Lam,Hong Kong Island,Hong Kong Special Administrative Region,China [4]Advanced Biomedical Instrumentation Center,Hong Kong Science Park,Pak Shek Kok,New Territories,Hong Kong Special Administrative Region,China [5]Margaret K.L.Cheung Research Center for Management of Parkinsonism,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,New Territories,Hong Kong Special Administrative Region,China [6]Lau Tat-chuen Research Center of Brain Degenerative Diseases in Chinese,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,New Territories,Hong Kong Special Administrative Region,China [7]Gerald Choa Neuroscience Institute,The Chinese University of Hong Kong,Shatin,New Territories,Hong Kong Special Administrative Region,China

出　　处：《Neural Regeneration Research》2024年第11期2351-2353,共3页中国神经再生研究（英文版）

基　　金：funded by a Croucher Innovation Award(CIA20CU01)from the Croucher Foundation;the General Research Fund(14100122);the Collaborative Research Fund(C6027-19GF&C7074-21GF);the Area of Excellence Scheme(AoE/M-604/16)of the Research Grants Council;the University Grants Committee of Hong Kong,China;the Excellent Young Scientists Fund(Hong Kong and Macao,China)(82122001)from the National Natural Science Foundation of China;the Lo’s Family Charity Fund Limited(all to HK).

摘　　要：Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in animals.Nevertheless,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal subject.Moreover,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain imaging.Additionally,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much needed.This is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.

关 键 词：dealing PRECISE SIZES 

分 类 号：O35[理学—流体力学] R318[理学—力学]