Human brain organoid:trends,evolution,and remaining challenges  

作　　者：Minghui Li Yuhan Yuan Zongkun Hou Shilei Hao Liang Jin Bochu Wang 

机构地区：[1]Key Laboratory of Biorheological Science and Technology,Ministry of Education,College of Bioengineering,Chongqing University,Chongqing,China [2]Southwest Hospital/Southwest Eye Hospital,Third Military Medical University(Army Medical University),Chongqing,China [3]School of Biology and Engineering/School of Basic Medical Sciences,Guizhou Medical University,Guiyang,Guizhou Province,China

出　　处：《Neural Regeneration Research》2024年第11期2387-2399,共13页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82204083(to ML)and 12372303(to BW);the Natural Science Foundation of Chongqing,No.cstc2021jcy-jmsxmX0171(to ML).

摘　　要：Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and diseases.Although various studies and reviews have described developments and advancements in brain organoids,few studies have comprehensively summarized and analyzed the global trends in this area of neuroscience.To identify and further facilitate the development of cerebral organoids,we utilized bibliometrics and visualization methods to analyze the global trends and evolution of brain organoids in the last 10 years.First,annual publications,countries/regions,organizations,journals,authors,co-citations,and keywords relating to brain organoids were identified.The hotspots in this field were also systematically identified.Subsequently,current applications for brain organoids in neuroscience,including human neural development,neural disorders,infectious diseases,regenerative medicine,drug discovery,and toxicity assessment studies,are comprehensively discussed.Towards that end,several considerations regarding the current challenges in brain organoid research and future strategies to advance neuroscience will be presented to further promote their application in neurological research.

关 键 词：bibliometric analysis brain organoids cerebral organoids global trends NEUROSCIENCE 

分 类 号：R318[医药卫生—生物医学工程]