左心耳封堵器在心房颤动临床救治中应用研究进展  

Research Progress in Application of Left Atrial Appendage Closure in Clinical Treatment of Atrial Fibrillation

作　　者：朱紫薇 张小卫[1] ZHU Ziwei;ZHANG Xiaowei(Department of Cardiology,Lanzhou University Second Hospital,Lanzhou 730000,China)

机构地区：[1]兰州大学第二医院心内科,兰州730000

出　　处：《医学综述》2024年第4期452-457,共6页Medical Recapitulate

基　　金：国家自然科学基金(82060080);甘肃省科技计划项目(20YF3WA016,21JR11RA116);甘肃省高等学校创新基金项目(2020B-024);兰州市人才创新创业项目(2019-RC-36)。

摘　　要：左心耳是心房颤动(简称房颤)患者形成血栓的主要部位。左心耳封堵术(LAAC)通过封堵左心耳预防房颤患者左心耳内血栓形成,从而降低房颤患者远期致残率和死亡率。此外,LAAC还可消除患者对长期口服抗凝治疗的依赖性,可为患者提供新的治疗方案。LAAC的成功实施在很大程度上依赖各种影像学手段,近年越来越多左心耳封堵器的临床应用不仅促进了LAAC术前检查的快速发展,而且为明确各种左心耳封堵器的优缺点及其预后提供了循证医学证据。未来仍需不断优化左心耳封堵器械的研发,以进一步提高LAAC的疗效和安全性。The left atrial appendage is the main site of thrombus formation in patients with atrial fibrillation.Left atrial appendage closure(LAAC)can prevent thrombus formation in the left atrial appendage of the patients with atrial fibrillation,thereby reducing the long-term disability and mortality rates.In addition,LAAC can eliminate the patient′s dependence on long-term oral anticoagulation therapy and provide new treatment options for the patients.The successful implementation of LAAC largely relies on various imaging techniques.In recent years,with the increasing use of left atrial appendage occluders in clinical practice,it has not only promoted the rapid development of preoperative examinations for LAAC,but also provided evidence-based medical evidence for clarifying the advantages,disadvantages,and prognosis of various types o fleft atrial appendage occluders.In the future,it is still necessary to continuously optimize the research and development of left atrial appendage occlusion devices to further improve the efficacy and safety of LAAC.

关 键 词：心房颤动 左心耳封堵器 左心耳结构 器械相关血栓 远期预后 

分 类 号：R714.252[医药卫生—妇产科学]