老年厌食症代谢变化的研究进展  

Research Progress of Metabolic Changes in Geriatric Anorexia

作　　者：詹莹莹 陈锐[1] 杨龙 ZHAN Yingying;CHEN Rui;YANG Long(Department of Gerontology,Shanghai Eighth People′s Hospital,Shanghai 200235,China)

机构地区：[1]上海市第八人民医院老年科,上海200235

出　　处：《医学综述》2024年第4期477-481,共5页Medical Recapitulate

基　　金：上海市徐汇区医学科研重大项目(SHXH201903);江苏大学临床医学科技发展基金项目(JLY20180130)。

摘　　要：老年厌食症是指与年龄相关的食欲减退或食物摄入量的减少。患有厌食症的老年人可出现营养不良和营养代谢障碍,这使得老年人的抵抗力下降,从而更容易带来不良健康后果。例如肌少症、活动能力下降,甚至可发展为生活自理能力丧失,导致残疾率、死亡率增加等。老年厌食症的发病机制包括一系列伴随衰老过程的代谢变化,如胆囊收缩素分泌增加,瘦素、胃饥饿素分泌减少,肠道菌群失调介导的炎症因子改变,这些代谢变化可作为该疾病的生物标志物。根据这些变化可早期识别老年厌食症,并能够研制专门的营养干预方案。今后可对老年人肠道微生物群及遗传因素是否影响营养状态进行相关研究,以为老年厌食症的有效防治提供新思路。Anorexia in the elderly refers to age-related loss of appetite or decrease in food intake.Elderly people with anorexia may experience malnutrition and nutritional metabolic disorders,which the elderly less resistant and therefore more prone to adverse health outcomes.For example,sarcopenia,decreased mobility,and even the loss of self-care ability can lead to increased disability and mortality.The pathogenesis of anorexia in the elderly includes a series of metabolic changes that accompany the aging process,such as the increased secretion of cholecystokinin,the decreased leptin and gastrin secretion,dysfunction of gut microbiota mediated changes in inflammatory factors.These metabolic changes can serve as biomarkers for this disease,which can be used to identify anorexia in the elderly at an early stage and develop special nutritional intervention programs.In the future,relevant research can be conducted on whether the gut microbiota and genetic factors of the elderly affect their nutritional status,so as to provide new ideas for the effective prevention and treatment of geraitric anorexia.

关 键 词：厌食症 老年 营养不良 代谢变化 

分 类 号：R442.1[医药卫生—诊断学]