骨髓间充质干细胞治疗骨关节炎的研究进展  

Advances in the study of bone marrow mesenchymal stem cells therapy on osteoarthritis

作　　者：刘昱航 林金盈[1] LIU Yuhang;LIN Jinying(Department of Rheumatology and Immunology,the People′s Hospital of Guangxi Zhuang Autonomous Region(Guangxi Academy of Medical Sciences),Nanning 530021,China)

机构地区：[1]广西壮族自治区人民医院(广西医学科学院)风湿免疫科,南宁530021

出　　处：《中国临床新医学》2024年第1期118-122,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西壮族自治区卫生健康委员会课题(编号:Z20180761)。

摘　　要：骨关节炎(OA)是全球最普遍且高致残率的疾病之一,特征是累及全关节的病变,包括软骨退化、骨重塑、骨赘形成和滑膜炎症。目前OA的非手术治疗均不能阻止OA的进展。骨髓间充质干细胞(BMSCs)是从骨髓中提取出的一种多能成体干细胞,具有多向分化、自我增殖、内分泌、旁分泌因子调节细胞和组织的增殖、凋亡、免疫反应等特点,发挥诱导细胞增殖、刺激血管生成、保护细胞免于凋亡和免疫调节等作用。在OA的治疗中BMSCs也得到越来越多的应用。该文对近年来BMSCs治疗OA的研究进展作一综述。Osteoarthritis(OA)is one of the most prevalent and highly disabling diseases worldwide,characterized by lesions involving the entire joint,including cartilage degeneration,bone remodeling,osteophyte formation,and synovial inflammation.At present,non-operative treatment of OA can not prevent the progression of OA.Bone marrow mesenchymal stem cells(BMSCs)are pluripotent stem cells derived from bone marrow that have the ability of multidirectional differentiation,self-proliferation,endocrine and paracrine factors to regulate cell and tissue proliferation,apoptosis,and immune response,etc.They play the role in inducing cell proliferation,stimulating angiogenesis,protecting cells from apoptosis and immune regulation.BMSCs have been increasingly used in the treatment of OA.This paper reviews the research progress of BMSCs in treatment of osteoarthritis in recent years.

关 键 词：骨关节炎 骨髓间充质干细胞 软骨 外泌体 

分 类 号：R684.3[医药卫生—骨科学]