基于“调神”理论针刺治疗慢性疲劳综合征的临床疗效及对外周血辅助性T细胞1/辅助性T细胞2平衡的影响  

Efficacy of acupuncture based on"Tiaoshen"theory for patients with chronic fatigue syndromeand its influence on balance of peripheral blood helper T cell 1/helper T cell 2

作　　者：万敏[1] 周林[1] WAN Min;ZHOU Lin(Department of Medical Laboratory Medicine,Wuhan Hospital of Traditional Chinese Medicine,Wuhan,Hubei 430050)

机构地区：[1]湖北省武汉市中医医院医学检验科,湖北武汉430050

出　　处：《河北中医》2024年第2期283-286,291,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：武汉市中医药科研项目(编号:WZ22Z18)。

摘　　要：目的观察基于“调神”理论指导的针刺治疗慢性疲劳综合征(CFS)患者的疗效及对外周血辅助性T细胞1(Th1)/Th2平衡的影响。方法将90例CFS患者按照随机数字表法分为2组,对照组45例予常规针刺法进行治疗,治疗组45例采用基于“调神”理论指导的针刺法治疗。2组均治疗4周。比较2组治疗前后疲劳量表-14(FS-14)、疲劳评定量表(FAI)、汉密尔顿焦虑量表(HAMA)评分及血清干扰素γ(IFN-γ)、白细胞介素4(IL-4)水平,并统计2组总有效率。结果治疗组总有效率93.33%(42/45),对照组总有效率77.78%(35/45),治疗组临床疗效优于对照组(P<0.05)。2组治疗后FS-14躯体疲劳评分、脑力疲劳评分及总分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。2组治疗后FAI、HAMA评分均较本组治疗前降低(P<0.05),且治疗组治疗后均低于对照组(P<0.05)。2组治疗后血清IFN-γ水平及IFN-γ/IL-4均较本组治疗前升高(P<0.05),且治疗组治疗后均高于对照组(P<0.05),2组治疗后IL-4水平均降低(P<0.05),且治疗组治疗后低于对照组(P<0.05)。结论基于“调神”理论指导的针刺治疗CFS患者疗效显著,能够改善患者疲劳、焦虑状态,促进Th1/Th2平衡。Objective To observe the efficacy of acupuncture based on"Tiaoshen"theory for patients with chronic fatigue syndrome(CFS)and its influence on balance of peripheral blood helper T cell 1(Th1)/helper T cell 2(Th2).Methods A total of 90 CFS patients were randomly assigned into the control group(n=45)and the treatment group(n=45),in which they were treated with routine acupuncture and acupuncture based on"Tiaoshen"theory,respectively.Treated for 4 weeks,the aim was to compare Fatigue Scale-14(FS-14),Fatigue Assessment Instrument(FAI),Hamilton Anxiety Scale(HAMA),serum interferon-γ(IFN-γ),interleukin-4(IL-4).The overall effective rate was assessed.Results The overall effective rate in the treatment group was better than that in the control group(93.33%[42/45]vs 77.78%[35/45],[P<0.05],respectively).After treatment,FS-14(physical fatigue,mental fatigue)scores in the both groups were significantly decreased(P<0.05),which decreased notably in the treatment group compared with the control group(P<0.05).FAI and HAMA scores in the both groups were significantly decreased(P<0.05),which were significantly lower in the treatment group than in the control group(P<0.05).IFN-γand IFN-γ/IL-4 in the both groups were significantly increased(P<0.05),the increase in the treatment group was more prevalent compared with the control group(P<0.05).IL-4 in the both groups was significantly decreased,the decrease in the treatment group was more common than the control group(P<0.05).Conclusion For CFS patients,acupuncture based on"Tiaoshen"theory has significant curative effect,which can improve fatigue and anxiety,and promote Th1/Th2 balance.

关 键 词：慢性疲劳综合征 针刺疗法 调神法 焦虑 

分 类 号：R245.31[医药卫生—针灸推拿学]