Chromene-based BioAIEgens:‘in-water’synthesis,regiostructure-dependent fluorescence and ER-specific imaging  

作　　者：Xu-Min Cai Yuting Lin Jianyu Zhang Ying Li Zhenguo Tang Xuedan Zhang Ying Jia Wenjin Wang Shenlin Huang Parvej Alam Zheng Zhao Ben Zhong Tang 

机构地区：[1]Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,International Innovation Center for Forest Chemicals and Materials,College of Chemical Engineering,Nanjing Forestry University,Nanjing 210037,China [2]School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,The Chinese University of Hong Kong,Shenzhen(CUHK-Shenzhen),Shenzhen 518172,China [3]Department of Chemistry,Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction,The Hong Kong University of Science and Technology,Hong Kong 999077,China [4]Clinical Translational Research Center of Aggregation-Induced Emission,School of Medicine,The Second Affiliated Hospital,School of Science and Engineering,The Chinese University of Hong Kong,Shenzhen(CUHK-Shenzhen),Shenzhen 518172,China

出　　处：《National Science Review》2023年第11期113-122,共10页国家科学评论（英文版）

基　　金：supported by the National Natural Science Foundation of China(21601087,52003228 and 32171724);the Shenzhen Key Laboratory of Functional Aggregate Materials(ZDSYS20211021111400001).

摘　　要：Exploration of artificial aggregation-induced emission luminogens(AIEgens)has garnered extensive interest in the past two decades.In particular,AIEgens possessing natural characteristics(BioAIEgens)have received more attention recently due to the advantages of biocompatibility,sustainability and renewability.However,the extremely limited number of BioAIEgens extracted from natural sources have retarded their development.Herein,a new class of BioAIEgens based on the natural scaffold of chromene have been facilely synthesized via green reactions in a water system.These compounds show regiostructure-,polymorphism-and substituent-dependent fluorescence,which clearly illustrates the close relationship between the macroscopic properties and hierarchical structure of aggregates.Due to the superior biocompatibility of the natural scaffold,chromene-based BioAIEgens can specifically target the endoplasmic reticulum(ER)via the introduction of tosyl amide.This work has provided a new chromene scaffold for functional BioAIEgens on the basis of green and sustainable‘in-water’synthesis,applicable regiostructure-dependent fluorescence,and effective ER-specific imaging.

关 键 词：CHROMENE BioAIE ‘in-water’chemistry regiostructure dependence ER-specific imaging 

分 类 号：TQ422[化学工程]