Chemerin、Gal-3、Visfatin与房颤患者首次导管射频消融术后复发的相关性  

The Correlation between Chemerin,Gal-3,Visfatin and Recurrence after First Catheter Radiofrequency Ablation in Patients with Atrial Fibrillation

作　　者：张莉侠 董锦丽 ZHANG Lixia;DONG Jinli(Department of Cardiology,The Center Hospital of Shangqiu,Shangqiu Henan 476000)

机构地区：[1]商丘市中心医院心内科,河南商丘476000

出　　处：《医学临床研究》2024年第1期18-21,共4页Journal of Clinical Research

摘　　要：【目的】探讨血清半乳糖凝集素3(Gal-3)、内脂素(Visfatin)、趋化素(Chemerin)水平与房颤患者首次导管射频消融术后复发的相关性。【方法】选取2019年8月至2021年8月本院收治的184例房颤患者,所有患者入院后均行射频消融术治疗,根据术后6个月内是否复发将其分为复发组(n=53)和未复发组(n=131)。比较两组临床资料及术前、术后1个月血清Chemerin、Gal-3、Visfatin水平,分析术后1个月上述指标与房颤术后复发的相关性及预测价值。【结果】复发组患者合并高血压、冠心病所占比例及左房容积指数(LAVI)高于未复发组,左心室射血分数(LVEF)低于未复发组,差异有统计学意义(P<0.05)。复发组术前、术后1个月血清Gal-3、Visfatin、Chemerin水平均高于未复发组,差异有统计学意义(P<0.05)。Logistic回归分析显示,术后1个月血清Gal-3、Visfatin、Chemerin高水平为术后房颤复发的独立危险因素(P<0.05)。Gal-3、Visfatin、Chemerin高水平患者术后房颤复发风险分别为低水平患者的4.076倍、2.847倍、6.272倍(P<0.05)。【结论】血清Gal-3、Visfatin、Chemerin与房颤患者首次射频消融术后复发密切相关,可早期预测患者术后复发风险,有助于临床医师针对性制定治疗方案,降低复发率。【Objective】To explore the correlation between serum levels of Galactin-3(Gal-3),Visfatin,and Chemerin and recurrence after first catheter radiofrequency ablation in patients with atrial fibrillation.【Methods】A total of 184 patients with atrial fibrillation admitted to our hospital from August 2019 to August 2021 were selected.All patients underwent radiofrequency ablation treatment after admission.They were divided into a recurrence group(n=53)and a non recurrence group(n=131)based on whether they recurred within 6 months after surgery.We compared two clinical data sets and serum levels of Chemerin,Gal-3,and Visfatin before and 1 month after surgery,and analyzed the correlation and predictive value of these indicators with postoperative recurrence of atrial fibrillation at 1 month after surgery.【Results】The proportion of recurrent group,concomitant hypertension,coronary heart disease,and left atrial volume index(LAVI)were higher than those of the non recurrent group,and the left ventricular ejection fraction(LVEF)was higher than those of the non recurrent group,with statistical significance(P<0.05).The serum levels of Gal-3,Visfatin,and Chemerin in the recurrent group were higher than those in the non recurrent group before and 1 month after surgery,with statistical significance(P<0.05).Logistic regression analysis showed that serum Gal-3,Visfatin,and Chemerin levels at one month post surgery were independent risk factors for postoperative atrial fibrillation recurrence(P<0.05).The risk of postoperative atrial fibrillation recurrence in patients with high levels of Gal-3,Visfatin,and Chemerin was 4.076 times,2.847 times,and 6.272 times higher than that in patients with low levels(P<0.05).【Conclusion】Serum Gal-3,Visfatin,and Chemerin are closely related to postoperative recurrence in patients with atrial fibrillation after the first radiofrequency ablation,which can predict the risk of postoperative recurrence in patients early and help clinical physicians formulate targeted treatment plans to redu

关 键 词：心房颤动/外科学 半乳糖凝集素3/血液 烟酰胺磷酸核糖基转移酶/血液 导管消融术 

分 类 号：R541.75[医药卫生—心血管疾病]