冠状动脉钙化积分与冠心病介入术后近期预后的相关性  

The Correlation between Coronary Artery Calcium Score and Short-Term Prognosis after Coronary Artery Disease Interventional Surgery

作　　者：张宏伟 李新国 ZHANG Hongwei;LI Xinguo(Department of Geriatric Cardiovascular Medical,North Campus,Xi'an International Medical Center/Yan'an University School of Medicine,Xi'an Shaanxi 710119)

机构地区：[1]西安国际医学中心北院区老年心血管内科,陕西西安710119 [2]延安大学咸阳医院心血管内科,陕西咸阳712000

出　　处：《医学临床研究》2024年第1期51-53,57,共4页Journal of Clinical Research

摘　　要：【目的】探讨冠状动脉钙化积分(CCS)与冠心病(CAD)介入术后近期预后的相关性。【方法】120例接受冠状动脉介入治疗的CAD患者,均施行冠状动脉CT血管造影检查(CTA),计算CCS。院外随访6个月,记录主要不良心血管事件(MACE)发生情况及无MACE生存时间,据此,将患者分为预后不良组(n=27)及预后良好组(n=93)。分析CCS与患者预后不良的关系及预测价值。【结果】预后不良组患者年龄、CCS、血肌酐(Scr)及氨基末端脑钠肽前体(NT-proBNP)均显著高于预后良好组(P<0.05),无MACE生存时间及左心室射血分数(LVEF)显著低于预后良好组(P<0.05);CCS与年龄(r=0.518,P<0.05)及Scr(r=0.407,P<0.05)呈正相关,而与LVEF(r=-0.215,P<0.05)呈负相关;受试者工作特征(ROC)曲线评估CCS预测MACE的曲线下面积(AUC)(95%CI)为0.84(0.76~0.92);CCS、LVEF及NT-proBNP与患者预后不良相关,其优势比(OR)(95%CI)分别为1.46(0.61~3.49)、1.01(0.98~1.05)及1.24(1.03~1.82)。【结论】CCS是接受介入治疗CAD患者近期预后不佳的独立危险因素,同时是潜在评估MACE的临床指标。【Objective】To explore the correlation between Coronary Artery Calcium Score(CCS)and the short-term prognosis of patients with Coronary Artery Disease(CAD)after interventional surgery.【Methods】A total of 120 patients who underwent coronary artery interventional treatment and coronary artery CT angiography(CTA)were included in the study.CCS was calculated for each patient.Patients were followed up for 6 months outside the hospital to record the occurrence of major adverse cardiac events(MACE)and the survival time without events.Based on those information,patients were divided into two groups:the poor prognosis group(n=27)and the good prognosis group(n=93).The relationship and predictive value of CCS in patients with their prognosis were analyzed.【Results】The age,CCS,serum creatinine(Scr),and N-terminal pro-brain natriuretic peptide(NT-proBNP)levels in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05).The time without MACE and Left Ventricular Ejection Fraction(LVEF)were significantly lower in the poor prognosis group compared to the good prognosis group(P<0.05).CCS showed a positive correlation with age(r=0.518,P<0.05)and Scr(r=0.407,P<0.05),and a negative correlation with LVEF(r=-0.215,P<0.05).The area under the curve(AUC)of the receiver operating characteristic(ROC)curve for predicting MACE using CCS was 0.84(95%CI:0.76-0.92).CCS,LVEF,and NT-proBNP were correlated with poor prognosis in patients,with odds ratios(OR)(95%CI)of 1.46(0.61-3.49),1.01(0.98-1.05),and 1.24(1.03-1.82),respectively.【Conclusion】CCS is an independent risk factor for poor short-term prognosis in patients undergoing interventional treatment for CAD and is a potential clinical indicator for assessing MACE.

关 键 词：冠心病 经皮冠状动脉介入治疗 冠状动脉疾病 预后 

分 类 号：R541.4[医药卫生—心血管疾病]