sVCAM1、MIF及IgE在支气管哮喘急性发作患者血清中的表达水平及其意义  

Clinical Significance of Serum sVCAM1,MIF and IgE in Patients with Acute Asthma

作　　者：梁彩艳 马敏 LIANG Caiyan;MA Min(Department of Pediatrics,Weinan Maternal and Child Health Hospital,Weinan Shaanxi 714000)

机构地区：[1]渭南市妇幼保健院儿科,陕西渭南714000 [2]富县人民医院儿科,陕西延安727500

出　　处：《医学临床研究》2024年第1期62-65,69,共5页Journal of Clinical Research

摘　　要：【目的】探讨可溶性血管内皮细胞表达的粘附因子(sVCAM1)、巨噬细胞迁移抑制因子(MIF)和免疫球蛋白E(IgE)在支气管哮喘急性发作期患者血清中的表达水平及其意义。【方法】选取2018年10月至2021年3月渭南市妇幼保健院收治的126例支气管哮喘急性发作患者(急性发作组)和110例支气管哮喘非急性发作患者(非急性发作组),另选择100例体检健康志愿者作为对照组,比较三组血清sVCAM1、MIF及IgE水平。统计支气管哮喘急性发作患者住院期间预后情况分为预后不良组和预后良好组,比较预后不良组和预后良好组的临床资料。Logistic多因素回归分析支气管哮喘急性发作患者预后的影响因素;采用受试者工作特征(ROC)曲线分析血清sVCAM1、MIF及IgE对支气管哮喘急性发作患者预后的预测价值。【结果】急性发作组、非急性发作组血清sVCAM1、MIF及IgE水平均高于对照组(P<0.05),且急性发作组患者血清sVCAM1、MIF及IgE水平高于非急性发作组(P<0.05)。本研究中支气管哮喘急性发作患者住院期间不良预后发生率为16.67%。预后不良组住院时间、病情为重度占比及sVCAM1、MIF、IgE水平均高于预后良好组(P<0.05),一秒用力呼气容积(FEV 1)/用力肺活量(FVC)低于预后良好组(P<0.05)。Logistic多因素分析结果显示:病情为重度及血清sVCAM1升高、MIF升高、IgE升高均是影响支气管哮喘急性发作患者预后的危险因素(OR=2.795、3.142、3.022、3.449,P<0.05)。ROC曲线分析结果显示:血清sVCAM1、MIF及IgE预测支气管哮喘急性发作患者预后的最佳截断点分别为467.92 ng/L、51.02 ng/mL、285.96 IU/mL,三者联合预测支气管哮喘急性发作患者预后的曲线下面积(AUC)为0.890,高于血清sVCAM1、MIF及IgE单独预测的AUC(P<0.05)。【结论】血清sVCAM1、MIF及IgE在支气管哮喘急性发作期患者血清中的表达水平异常升高,且三者联合预测支气管哮喘急性发作期患�【Objective】To explore the changes of adhesion factor(sVCAM1),macrophage migration inhibitory factor(MIF)and immunoglobulin E(IgE)expressed by serum soluble vascular endothelial cells during the acute attack of bronchial asthma and their prognostic value.【Methods】A total of 126 patients with acute attack of bronchial asthma and 110 patients with non-acute attack of bronchial asthma admitted to our hospital from October 2018 to March 2021 were recorded as acute attack group and non-acute attack group,respectively,and 100 healthy volunteers were recorded as the control group.The serum sVCAM1,MIF and IgE levels of the three groups of subjects were compared.The prognosis of patients with acute attack of bronchial asthma was analyzed and divided into the poor prognosis group and the good prognosis group according to treatment progress and recovery degree.The clinical data of the poor prognosis group and the good prognosis group were compared.Logistic multivariate regression analysis of factors affecting the prognosis of patients with acute bronchial asthma attacks.A receiver operating characteristic curve(ROC)was made to analyze the predictive value of serum sVCAM1,MIF and IgE on the prognosis of patients with acute bronchial asthma attacks.【Results】The serum sVCAM1,MIF and IgE levels of the three groups were compared,and the differences were statistically significant(P<0.05).The levels of serum sVCAM1,MIF and IgE in the acute attack group were higher than those in the non-acute attack group and the control group(P<0.05).The serum sVCAM1,MIF and IgE levels of patients in the acute attack group were higher than those in the non-acute attack group(P<0.05).In this study,the incidence of adverse prognosis in patients with acute attack of bronchial asthma during hospitalization was 16.67%.The hospital stay,severity ratio,sVCAM1,MIF and IgE in the poor prognosis group were higher than those in the good prognosis group(P<0.05),and the forced expiratory volume in one second(FEV 1)/forced lung capacity(FVC)in the po

关 键 词：哮喘 症状爆发 巨噬细胞游走抑制因子/血液 免疫球蛋白E/血液 

分 类 号：R562.25[医药卫生—呼吸系统]