Catalytic asymmetric synthesis of sulfur-containing atropisomers by C-S bond formations  

作　　者：Ren-Fei Cao Zhi-Min Chen 

机构地区：[1]School of Chemistry and Chemical Engineering,Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Science China Chemistry》2023年第12期3331-3346,共16页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (22071149,21871178);the Natural Science Foundation of Shanghai (23ZR1428200);the Program for Professor of Special Appointment (Eastern Scholar)at Shanghai Institutions of Higher Learning。

摘　　要：Chiral organosulfur compounds are not only widely distributed in bioactive natural products and pharmaceuticals,but also play a significant role in chiral ligands/catalysts.Throughout the history of synthetic organic chemistry,chemists have been absorbed in the construction of centrally chiral organosulfur compounds.Nevertheless,there are relatively few reports on installing sulfur functional groups into axially chiral compounds.Atropisomerism is one of the fundamental phenomena in nature,which ubiquitously exists in natural products.After more than a century of development,atropisomers have been designed and extensively applied to pharmaceuticals,functional materials and chiral ligands/catalysts.Due to the importance of chiral sulfurcontaining atropisomers,there is an increasing demand for enantioselective synthesis of them.Recently,a diversity of approaches by C-S bond formations have been established for the construction of enantioenriched sulfur-containing atropisomers,however,there is no comprehensive review to summarize this great progress.In this mini-review,we summarize recent progress in catalytic asymmetric synthesis of sulfur-containing atropisomers by C-S bond formations,which includes sulfur nucleophilic reactions,sulfur electrophilic reactions and sulfur radical reactions.Furthermore,the reaction mechanisms are also discussed.We hope that this mini-review will enable more researchers to further explore this field.

关 键 词：ATROPISOMERS asymmetric catalysis C-S bond formations chiral organosulfur compounds 

分 类 号：O623.8[理学—有机化学]