Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-disubstituted alkenes enabling the modular synthesis of 1,1,2,2-tetraarylethanes  

作　　者：Chengxi Zhang Yang Xi Jingping Qu Yifeng Chen 

机构地区：[1]Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering,Feringa Nobel Prize Scientist Joint Research Center,Frontiers Science Center for Materiobiology and Dynamic Chemistry,School of Chemistry and Molecular Engineering,East China University of Science&Technology,Shanghai 200237,China

出　　处：《Science China Chemistry》2023年第12期3539-3545,共7页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (22171079);the Natural Science Foundation of Shanghai (21ZR1480400);the Shanghai Rising-Star Program (20QA1402300);the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03);the Program of Introducing Talents of Discipline to Universities (B16017);the Fundamental Research Funds for the Central Universities。

摘　　要：The highly diastereoselective dicarbofunctionalization of substituted olefins still remains a daunting challenge in synthetic chemistry.Herein,we report a Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-diarylethylene with chelation group free to enable the modular synthesis of smart material candidates,1,1,2,2-tetraarylethanes(TAEs),which represent the first protocol by assembling four different aryl groups into ethane motif.Preliminary mechanistic experiments suggest that the crucial Pd–H species generated in situ do not disengage from the alkene intermediate during the reaction.

关 键 词：1 1 2 2-tetraarylethane PALLADIUM cross-coupling reaction ALKENE multicomponent reactions 

分 类 号：O625.1[理学—有机化学] O621.251[理学—化学]