A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation  

作　　者：Yuxuan Guo Yangpo Cao Blake D.Jardin Neil Mazumdar Congting Guo Luzi Yang Junsen Lin Zhan Chen Qing Ma Mingming Zhao Erdan Dong William T.Pu 

机构地区：[1]Peking University Health Science Center,School of Basic Medical Sciences,Beijing 100191,China [2]Peking University Institute of Cardiovascular Sciences,Beijing 100191,China [3]State Key Laboratory of Vascular Homeostasis and Remodeling,Peking University,Beijing,100191,China [4]Beijing Key Laboratory of Cardiovascular Receptors Research,Beijing 100191,China [5]Boston Children’s Hospital,Department of Cardiology,Boston MA 02115,USA [6]Peking University Third Hospital,Department of Cardiology and Institute of Vascular Medicine,Beijing 100191,China [7]Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases,Chinese Academy of Medical Sciences,Haihe Laboratory of Cell Ecosystem,Beijing 100191,China [8]National Health Commission Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Beijing 100191,China [9]Harvard Stem Cell Institute,Cambridge MA 02138,USA

出　　处：《Science China(Life Sciences)》2023年第12期2939-2942,共4页中国科学（生命科学英文版）

基　　金：supported by the National Key Research and Development Program of China (2022YFA1104800);the National Natural Science Foundation of China (82222006,32100660,82170367);Beijing Nova Program (Z211100002121003,20220484205);Beijing Natural Science Foundation (7232094);supported by National Institute of Health (R01HL146634 and UM1HL098166);supported by the Natural Science Foundation of China (82070235 and 92168113);the CAMS Innovation Fund for Medical Sciences (2021-I2M-5003);Haihe Laboratory of Cell Ecosystem Innovation Fund (HH22KYZX0047)。

摘　　要：Dear Editor,In development,after cells make a commitment to their fates,they undergo a continuous and adaptive maturation process to eventually reach their terminal states.Cell maturity often decays during aging and pathogenesis.The immature phenotypes of stem cell-differentiated cells deposit a major bottleneck in regenerative medicine.

关 键 词：STATES eventually DECAY 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]