2型糖尿病患者低胆红素水平与甲状腺功能亢进相关性的研究  

Correlation between low bilirubin levels and hyperthyroidism in patients with type 2 diabetes mellitus

作　　者：刘文[1] 史磊[1] 汪静[1] LIU Wen;SHI Lei;WANG Jing(Department of Endocrinology,The Fourth Hospital of Baotou,Baotou 014030,China)

机构地区：[1]包头市第四医院内分泌科,014030

出　　处：《中国糖尿病杂志》2024年第1期42-45,共4页Chinese Journal of Diabetes

摘　　要：目的探讨T2DM患者低胆红素(T-BIL)水平与甲状腺功能亢进(甲亢)的相关性。方法选取2019年1月至2022年8月于我院内分泌科诊治的T2DM患者186例,根据是否合并甲亢分为单纯T2DM组(n=107)和甲亢组(HT,n=79),Logistic回归分析T2DM患者合并甲亢的影响因素。结果与T2DM组比较,HT组DM病程、FPG、食盐摄入量大占比、精神易紧张占比升高(P<0.05),BMI、T-BIL降低(P<0.05)。Pearson相关分析显示,T-BIL与促甲状腺激素(TSH)呈正相关(P<0.05),与总三碘甲状腺原氨酸、总甲状腺素、游离三碘甲腺原氨酸(FT3)、游离甲状腺素呈负相关(P<0.05)。Logistic回归分析结果显示,DM病程、食盐摄入量大、FPG和T-BIL是T2DM患者合并甲亢的影响因素。受试者工作特征(ROC)曲线分析显示,ROC曲线下面积为0.812,敏感度为87.4%,特异度为82.6%。结论T-BIL与TSH、FT3显著相关,低T-BIL水平是T2DM患者合并甲亢的危险因素,对预测T2DM患者是否合并甲亢有重要意义。Objective To explore the relationship between low bilirubin(T-BIL)levels and hyperthyroidism in patients with type 2 diabetes mellitus(T2DM).Methods A total of 186 patients with T2DM admitted to the Endocrinology Department of our hospital were enrolled in this study from January 2019 to August 2022.They were divided into simple T2DM group(n=107)and hyperthyroidism group(HT,n=79)according to whether they were complicated with hyperthyroidism.The influence factors for T2DM patients complicated with hyperthyroidism were evaluated by logistic regression analysis.Results Compared with T2DM group,DM duration,FPG,the proportion of patients with salty taste and nervous increased in HT group(P<0.05),while BMI,T-BIL decreased in HT group(P<0.05).Pearson correlation analysis showed that T-BIL was positively correlated with TSH levels(P<0.05),and negatively correlated with TT3,TT4,FT3and FT4(P<0.05).Logistic regression analysis showed that DM duration,salty taste,FPG and T-BIL were the influencing factors of T2DM patients with hyperthyroidism.The receiver operating characteristic(ROC)Curve showed that the AUC of the model was 0.812(95%CI 0.748~0.839),with sensitivity and specificity 87.4%and 82.6%respectively.Conclusion T-BIL was significantly correlated with TSH and FT3.Low T-BIL level is an independent risk factor for T2DM patients with hyperthyroidism,which is of great significance for predicting whether T2DM patients complicated with hyperthyroidism.

关 键 词：糖尿病 2型 甲状腺功能亢进 低胆红素水平 危险因素 

分 类 号：R587.2[医药卫生—内分泌] R581.1[医药卫生—内科学]