IL-23和RvE1在桥本甲状腺炎炎症调控中的潜在作用  

Potential Roles of IL-23 and RvE1 in the Regulation of Inflammation in Hashimoto’s

作　　者：王磊 张超[1] Wang Lei;Zhang Chao(The First Affiliated Hospital of Jiamusi University,Jiamusi 154000,China)

机构地区：[1]佳木斯大学附属第一医院,黑龙江佳木斯154000

出　　处：《黑龙江科学》2024年第4期119-123,共5页Heilongjiang Science

摘　　要：桥本甲状腺炎是一种常见的自身免疫性疾病,其特征是甲状腺特异性自身抗体的存在,目前其发病机制尚未完全明确,但与遗传、环境及表观遗传因素的相互作用有关。疾病的发展主要涉及细胞免疫和体液免疫,经常出现T细胞和B细胞的炎症浸润。在组织病理学上,IL-23是一种重要的细胞因子,在先天免疫和适应性免疫中发挥作用,是促进多种靶器官炎症反应的关键因子。Resolvin E1(RvE1)是一种内源性脂质介质,源于二十碳五烯酸(EPA),在许多疾病模型中显示出保护作用。综述了IL-23和RvE1在桥本甲状腺炎炎症调控中的潜在作用,以期开发更精准的治疗方法,改善患者生活质量,降低相关并发症的风险。Hashimoto’s thyroiditis is a common autoimmune disease characterized by the presence of thyroid-specific autoantibodies.It is characterized by the presence of thyroid-specific autoantibodies,and its pathogenesis is not fully understood.But it is related to the interaction of genetic,environmental and epigenetic factors.The development of the disease mainly involves cellular and humoral immunity,often with inflammatory infiltration of T cells and B cells.In histopathology,IL-23 is an important cytokine that plays a role in innate and adaptive immunity,and is a key factor in promoting inflammatory responses in multiple target organs.Resolvin E1(RvE1)is an endogenous lipid mediator derived from eicosapentaenoic acid(EPA)that has shown protective effects in many disease models.The study reviews the potential role of IL-23 and RvE1 in the regulation of Hashimoto’s thyroiditis,so as to develop more accurate treatment,improve patients’quality of life,and reduce the risk of related complications.

关 键 词：桥本氏甲状腺炎 发病机制 白介素23 Resolvin E1 诊断 

分 类 号：R581.4[医药卫生—内分泌]