深圳市男男性行为者HIV暴露后预防的使用:一项系列横断面研究  

Utilization of post-exposure prophylaxis among MSM in Shenzhen:A serial cross-sectional study

作　　者：戴德磊 杨梓杰 张燕[2] 谭唯[2] 杨峥嵘[2] 刘少础[2] 谢炜[2] 卫兰 李思美 袁苑 袁小洪 唐虎 朱悦 赵锦 DAI Delei;YANG Zijie;ZHANG Yan;TAN Wei;YANG Zhengrong;LIU Shaochu;XIE Wei;WEI Lan;LI Simei;YUAN Yuan;YUAN Xiaohong;TANG Hu;ZHU Yue;ZHAO Jin(School of Public Health,Shantou University,Shantou 515063,Guangdong,China;Shenzhen Center for Disease Control and Prevention,Shenzhen 518000,Guangdong,China;Peking University,Beijing 100083,China;School of Public Health,Sun Yat-sen University,Guangzhou 510080,Guangdong,China;School of Public Health,Shanxi Medical University,Taiyuan 030607,Shanxi,China;Southern Medical University,Guangzhou 510515,Guangdong,China)

机构地区：[1]汕头大学公共卫生学院,广东汕头515063 [2]深圳市疾病预防控制中心,广东深圳518000 [3]北京大学,北京100083 [4]中山大学公共卫生学院,广州510080 [5]山西医科大学公共卫生学院,山西太原030607 [6]南方医科大学,广州510515

出　　处：《中国艾滋病性病》2024年第1期18-22,共5页Chinese Journal of Aids & STD

基　　金：国家自然科学基金(82373651);深圳市医学重点学科建设经费(SZXK064);深圳市医疗卫生三名工程(SZSM202311015)。

摘　　要：目的分析2020-2022年深圳市MSM的nPEP使用情况及其影响因素。方法2020年1月至2022年12月,在深圳市通过与社会组织合作招募MSM开展问卷调查,收集人口学、行为学以及nPEP使用等信息。采用χ2检验和Logistic回归分析nPEP使用的影响因素。结果共2900名研究对象纳入分析,2020-2022年深圳市MSM中三年的nPEP使用率依次为7.00%(55/787)、5.00%(59/1183)和5.59%(52/930)。多因素Logistic回归结果显示:有药物滥用(aOR=1.720,95%CI:1.242~2.381)、近一年在诊所或男同场所接受艾滋病相关服务(aOR=1.741,95%CI:1.068~2.836)、有启动PrEP的意愿(aOR=3.299,95%CI:2.256~4.832)、过去一年确诊患有性传播疾病(aOR=1.849,95%CI:1.139~3.000)、有做包皮环切术的历史(aOR=1.591,95%CI:1.029~2.459)的MSM使用nPEP的概率更高,而有固定性伴侣的MSM(aOR=0.532,95%CI:0.375~0.755)、有套肛交性行为(aOR=0.377,95%CI:0.230~0.619)使用nPEP的概率更低。结论2020-2022年深圳市MSM的nPEP使用率不高,有必要开展针对性的教育宣传,重点关注有固定性伴侣和有套肛交性行为的人群,提高nPEP使用率。Objective To analyze the utilization of non-occupational post-exposure prophylaxis(nPEP)among men who have sex with men(MSM)in Shenzhen from 2020 to 2022,and its influencing factors.Methods From January 2020 to December 2022,a questionnaire survey was conducted in Shenzhen City by recruiting MSM in collaboration with social organizations,and demographic,behavioral,and PEP utilization information were collected.Theχ2 test and logistic regression were used to analyze the influencing factors of PEP use.Results A total of 2900 respondents were included,and the annual PEP utilization rates among MSM in Shenzhen City from 2020 to 2022 were 7.00%(55/787),5.00%(59/1183),and 5.59%(52/930),respectively.Multivariate logistic regression results showed that MSM with substance abuse(aOR=1.720,95%CI:1.242-2.381),receipt of HIV-related services at a clinic or gay men's establishment in the past year(aOR=1.741,95%CI:1.068-2.836),willingness to initiate pre-exposure prophylaxis(PrEP)(aOR=3.299,95%CI.2.256-4.832),a diagnosis of a sexually transmitted disease in the past year(aOR=1.849,95%CI:1.139-3.000),a history of circumcision(aOR=1.591,95%CI:1.029-2.459)had a higher probability of using nPEP,while MSM with a regular sexual partner(aOR=0.532,95%CI:0.375-0.755),and those with condom anal sex(aOR=0.377,95%CI:0.230-0.619)were less likely to use nPEP.Conclusions PEP utilization among MSM in Shenzhen is relatively low from 2020 to 2022.It is necessary to carry out targeted educational campaigns,focusing on those with regular sexual partners and condom anal sex,to increase PEP utilization rate.

关 键 词：艾滋病病毒 非职业暴露后预防 男男性行为者 影响因素 

分 类 号：R512.91[医药卫生—内科学]