艾滋病病毒流行重组毒株CRF01_AE及其影响  

HIV-1 recombinant CRF01_AE and their impact on global AIDS pandemic

作　　者：李斯斯[1,2] 李康 Abdur Rashid 贺江珊[2,4] 王沛葭 刘茂顺 冯毅 邵一鸣 LI Sisi;LI Kang;Abdur Rashid;HE Jiangshan;WANG Peijia;LIU Maoshun;FENG Yi;SHAO Yiming(Guangxi Key Laboratory of AIDS Prevention and Treatment,School of Public Health,Guangxi Medical University,Nanning 530021,Guangxi,China;National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,National Center for AIDS/STD Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Nankai University,Tianjin 300071,China;Beijing Normal University,Beijing 100875,China)

机构地区：[1]广西艾滋病防治研究重点实验室公共卫生学院广西医科大学,南宁530021 [2]中国疾病预防控制中心性病艾滋病预防控制中心,北京102206 [3]南开大学,天津300071 [4]北京师范大学,北京100875

出　　处：《中国艾滋病性病》2024年第1期79-83,共5页Chinese Journal of Aids & STD

基　　金：国家自然科学基金(81361120407)。

摘　　要：CRF01_AE作为HIV最主要的流行重组毒株,在全球范围长时序演变,形成区域间的流行特征,构成特色且独立的流行与传播模式,本文从其起源、遗传多样性、流行特征及其对诊断和治疗延迟、疾病进程、治疗效果影响等方面进行综述,阐释CRF01_AE及时监测对遏制HIV区域间和全球蔓延的作用。As the most prevalent recombinants of HIV-1 globally,CRF01_AE plays an increasingly prominent role in HIV-1 long-time viral evolution with regional variation and distinct global distributions and transmissions.This review provides an update on origin,viral variation,epidemiology,impacts on disease progression,timely accessibility of healthcare services,and treatment pertinent to CRF01_AE.Noticeably,ongoing CRF01_AE recombination necessitates continued and improved surveillance of HIV-1 molecular epidemiology,which is crucial to curbing the regional HIV-1 transmission and achieving the global"End AIDS"target.

关 键 词：艾滋病 亚型 重组 流行病学 

分 类 号：R512.91[医药卫生—内科学]