艾滋病合并进行性多灶性脑白质病研究进展  

Research progress of progressive multifocal leukoencephalopathy in AIDS patients

作　　者：毛元岱 马萍[2] MAO Yuandai;MA Ping(Nankai University,Tianjin 300071,China;Tianjin Second People's Hospital,Tianjin 300019,China)

机构地区：[1]南开大学,天津300071 [2]天津市第二人民医院,天津300019

出　　处：《中国艾滋病性病》2024年第1期89-93,共5页Chinese Journal of Aids & STD

摘　　要：进行性多灶性脑白质病(PML)是由John Cunningham病毒(JCV)引起的亚急性脱髓鞘脑病,大多数PML患者合并艾滋病,发病后未经治疗的患者预后较差。本综述总结了JCV的感染及发病过程;JCV与免疫细胞及HIV之间的相互作用;结合核磁共振成像、磁敏感加权成像、脑脊液聚合酶链式反应等方法进行早期诊断;目前的治疗方案,包括经典的抗反转录病毒治疗(直接抗病毒治疗和免疫重建治疗),免疫检查点抑制剂,CRISPER/Cas9,T细胞疗法;抗病毒治疗药物开发的阻碍。Progressive multifocal leukoencephalopathy(PML)is a subacute demyelinating encephalopathy caused by the John Cunningham virus(JCV).PML is most commonly found in patients with AIDS,and the prognosis for untreated patients is poor.This review summarizes the infection and pathogenesis of JCV;the interactions between the JCV virus,immune cells,and HIV;methods for early diagnosis,including magnetic resonance imaging,magnetic susceptibilityweighted imaging,and cerebrospinal fluid polymerase chain reaction;the current therapeutic regimens,such as classical antiretroviral therapy(direct antiviral therapy and immune reconstitution therapy),immune checkpoint inhibitors,CRISPER/Cas9,T cell therapy;and barriers to the development of antiviral drugs.

关 键 词：进行性多灶性脑白质病 艾滋病病毒 JC病毒 抗病毒治疗 免疫检查点抑制剂 

分 类 号：R512.91[医药卫生—内科学]