磺胺类抗生素氯消毒副产物及其毒性研究进展  

Research Progress on Chlorinated Disinfection By-products of Sulfonamide Antibiotics and Their Toxicity

作　　者：高品[1] 蔡如 徐庆 秦艳[1] GAO Pin;CAI Ru;XU Qing;QIN Yan(College of Environmental Science and Engineering,Donghua University,Shanghai 201620,China;Shanghai Environmental Monitoring Center,Shanghai 200235,China)

机构地区：[1]东华大学环境科学与工程学院,上海201620 [2]上海市环境监测中心,上海200235

出　　处：《中国给水排水》2024年第2期50-54,共5页China Water & Wastewater

基　　金：国家自然科学基金资助项目(51978136)。

摘　　要：水中微量抗生素等新污染物的潜在毒性已受到广泛关注。磺胺类抗生素在氯消毒过程中会转化生成氯代消毒副产物(DBPs),造成环境健康风险。归纳了水中磺胺类抗生素在游离氯(FC)、二氧化氯(ClO2)和紫外(UV)/FC消毒体系中的降解转化途径,总结了磺胺类抗生素氯代DBPs的毒性效应,初步探讨了磺胺类抗生素氯代DBPs对细菌抗药性及水平基因转移的潜在影响,并对磺胺类抗生素作为氯代DBPs前体物的未来研究方向提出了展望,以期为磺胺类抗生素在氯化消毒下的生态风险评估和污染控制提供基础和依据。The potential toxicity of antibiotics and other emerging contaminants in water has attracted widespread attention.Chlorinated disinfection by-products(DBPs)can be produced from sulfonamide antibiotics during the chlorine disinfection process,resulting in risks to human health.In this study,the transformation pathways of sulfonamide antibiotics in the disinfection processes using free chlorine(FC),chlorine dioxide(ClO2),and UV/FC are summarized,respectively.The toxicity of the chlorinated DBPs is discussed.In addition,the potential effects of these chlorinated DBPs from sulfonamide antibiotics on the bacterial resistance and horizontal gene transfer were also studied.Finally,the future research directions of sulfonamide antibiotics as precursors of chlorinated DBPs in water are proposed.The purpose of this work is to provide basis for ecological risk assessment and pollution control of sulfonamide antibiotics during chlorine disinfection.

关 键 词：磺胺类抗生素 氯消毒 消毒副产物 毒性 细菌抗药性 

分 类 号：TU991[建筑科学—市政工程]