脓毒症内表型——随时间和空间变化  

Sepsis endotype-changes over time and space

作　　者：王春霞 张育才 Wang Chunxia;Zhang Yucai(Department of Critical Care Medicine,Shanghai Children's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200062,China;Laboratory of Critical Care Translational Medicine,Institute of Pediatric Infection,Immunity,and Critical Care Medicine,Shanghai Children's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200062,China)

机构地区：[1]上海市儿童医院,上海交通大学医学院附属儿童医院重症医学科,200026 [2]上海交通大学医学院儿童感染免疫与重症医学研究院危重症转化医学研究室,200026

出　　处：《中国小儿急救医学》2024年第1期8-13,共6页Chinese Pediatric Emergency Medicine

基　　金：国家自然科学基金项目(82171729)。

摘　　要：脓毒症异质性是影响其临床疗效和预后的关键因素。多组学技术和整合功能生物学发展促进了机器学习和智能算法在脓毒症异质性内在分子机制的研究,经转录组、蛋白质组、表观遗传组以及外泌体特征谱等多角度分析,提出了脓毒症内表型概念,使脓毒症可以分为临床亚型、代谢亚型、免疫亚型等。脓毒症内表型认知逐步拓展至诊断、危重度评估、临床研究患者筛选、个体化诊疗等多个层面,为脓毒症精准干预带来新思路。The heterogeneity of sepsis plays critical roles in determining the response of clinical intervention and the outcome of sepsis.Based on the host-response revealed from multiomics,the new idea of the endotype of sepsis was revealed from multiple perspectives,such as transcriptome,proteome,epigenome,and exosome signature spectrum,etc.In recent years,in the field of sepsis endotype,the research of clinical subtype,metabolic subtype,and immune subtype is booming.This concept has gradually penetrated into multiple aspects,including the diagnosis,severity assessment,patients screening for clinical research,and the reference for individualized clinical treatment.It brings a new perspective for clinical individualized treatment of sepsis.

关 键 词：脓毒症 异质性 内表型 多组学 

分 类 号：R459.7[医药卫生—急诊医学]