多巴胺对脓毒症中巨噬细胞功能的调控及机制研究  

Regulation effect of dopamine on sepsis-associated macrophage functions and the mechanisms involved

作　　者：宋文汀 张银凤 杜白露 莫茜 曹清[1] Song Wenting;Zhang Yinfeng;Du Bailu;Mo Xi;Cao Qing(Department of Infectious Disease,Shanghai Children’s Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China)

机构地区：[1]上海交通大学附属儿童医学中心感染科,200127 [2]上海交通大学附属儿童医学中心转化所,200127

出　　处：《中国小儿急救医学》2024年第1期52-56,共5页Chinese Pediatric Emergency Medicine

摘　　要：脓毒症是一种由宿主对感染的反应失调所引起的危及生命的器官功能障碍,巨噬细胞作为机体内最重要的固有免疫细胞之一,可通过招募其他免疫细胞、清除病原、呈递抗原等方式维持机体免疫稳态,并通过释放炎症因子等方式在脓毒症等感染性疾病中发挥重要的调节作用。多巴胺作为一种重要的神经递质,不仅参与学习、认知等神经活动过程,还可以调节免疫进程,调控包括中性粒细胞、淋巴细胞、单核巨噬细胞在内的免疫细胞的活化、增殖及功能改变等。在脓毒症的炎症反应过程中,巨噬细胞的吞噬、极化功能及炎症因子释放功能均受多巴胺的调控。本文就多巴胺在脓毒症中对巨噬细胞功能的调控作用及机制的最新研究进展进行综述。Sepsis is a life-threatening organ dysfunction caused by the host disordered response to infections.As one of the most important innate immune cells in the body,macrophages can maintain the immune homeostasis by recruiting other immune cells,clearing pathogens,presenting antigens,and play important regulatory roles in infectious diseases such as sepsis by releasing inflammatory factors.As a critical neurotransmitter,dopamine not only participates in the neurological processes such as learning and cognition,but also regulates the immune processes,including regulating the activation,proliferation and functional changes of immune cells such as neutrophils,lymphocytes,monocytes and macrophages.Current studies demonstrate that during the infection and inflammation process of sepsis,the phagocytosis,polarization,and release of inflammatory factors of macrophages are regulated by dopamine.This review summarized the recent research progress on the regulatory functions and the underlying mechanisms of dopamine on macrophages in sepsis.

关 键 词：多巴胺 脓毒症 巨噬细胞 炎症 调控机制 

分 类 号：R459.7[医药卫生—急诊医学]