Open-vessel Synthesis of Poly-N-methoxyethylglycine  

作　　者：LIU Guojan MA Ke CHEN Qi ZHANG Donghui LIU Runhui 

机构地区：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai,200237,P.R.China [2]Key Laboratory for Ultrafine Materials of Ministry of Education,Frontiers Science Center for Materiobiology and Dynamic Chemistry,Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,Research Center for Biomedical Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai,200237,P.R.China [3]School of Biotechnology,East China University of Science and Technology,Shanghai,200237,P.R.China

出　　处：《Chemical Research in Chinese Universities》2024年第1期153-158,共6页高等学校化学研究（英文版）

基　　金：the National Key Research and Development Program of China(No.2022YFC2303100);the National Natural Science Foundation of China(Nos.22075078,22205063);the Shanghai Sailing Program,China(No.22YF1410100);the Fund of the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education Commission),China.

摘　　要：Polypeptoids are widely used in biological applications owing to their diverse functions and proteolytic stability.One type of polypeptoids,poly-N-methoxyethylglycine(P-Nmeg),has been found to possess remarkable hydrophilicity and notable properties in terms of protein,cell,and bacterial antifouling.However,the currently known synthesis methods of P-Nmeg include solid-phase synthesis,which is time-consuming and difficult to scale up,and N-substituted N-carboxyanhydride(NNCA)ring-opening polymerization,whose monomers were difficult to store.In this study,we used the chemical stable Nmeg N-phenoxycarbonyl(NPC)as the monomer,which was obtained without the use of highly toxic reactants,such as phosgene or phosphorus halide,to synthesize P-Nmeg under open-vessel conditions.By adding BnNH_(2) as an initiator at 80℃,we can obtain controllable short chain length P-Nmeg with narrow dispersity.

关 键 词：Open-vessel Polypeptoid synthesis Poly-N-methoxyethylglycine Stable monomer Narrow dispersity 

分 类 号：O62[理学—有机化学]