基于数据挖掘探析郑卫琴治疗肺结节的用药规律  

Medication rule of Zheng Weiqin in treatment of pulmonary nodules:A study based on data mining

作　　者：刘平宇 徐昕怡 刘文琴[2] 唐晓慧 宋娜[2] 程俊[2] LIU Pingyu;XU Xinyi;LIU Wenqin;TANG Xiaohui;SONG Na;CHENG Jun(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]重庆市中医院,重庆400021

出　　处：《湖南中医杂志》2023年第12期34-38,共5页Hunan Journal of Traditional Chinese Medicine

基　　金：重庆市科研机构绩效激励引导专项项目(2018-1-1);国家中医药管理局郑卫琴名中医工作室建设项目。

摘　　要：目的:基于数据挖掘探析郑卫琴教授运用中医药治疗肺结节的组方用药规律。方法:收集2021年9月1日至2022年9月1日郑教授治疗肺结节的有效验案,并建立数据库,运用频次、药性、药味、归经统计,关联规则Apriori算法,系统聚类算法进行统计分析。结果:共收集病例56例,处方143首,高频药物有炙甘草、黄芪、陈皮、法半夏、白术、太子参、山药、五味子、川芎、芦根等;药性以温、平、寒、微寒为主,药味以甘、苦、辛为主,主要归肺、胃、肝、脾经;功效以补虚、清热、化痰止咳平喘、解表、理气为主;系统聚类分析得出5个核心药组。结论:郑教授治疗肺结节注重“扶土达木”,常用补肺健脾、疏肝理气、化痰散结之法,同时兼护胃气,用药多以甘缓急,并以辛开苦降、寒温并用为特色。Objective:To investigate the prescription and medication rules of Professor Zheng Weiqin in the treatment of pulmonary nodules using traditional Chinese medicine(TCM)based on data mining.Methods:The proven cases of pulmonary nodules treated by Professor Zheng from September 1,2021 to September 1,2022 were collected,and a database was established.Statistical analyses were performed in terms of frequency,nature,taste,and meridian entry,and the association rule Apriori algorithm and the hierarchical clustering algorithm were also used for analysis.Results:A total of 56 cases were collected,with 143 prescriptions in total.High-frequency drugs included Radix Glycyrrhizae Preparata,Astragalus membranaceus,tangerine peel,Rhizoma Pinelliae Praeparatum,Atractylodes macrocephala Koidz.,Radix Pseudostellariae,Dioscorea opposita,Schisandra chinensis,Rhizoma Chuanxiong,and Rhizoma Phragmitis.Most drugs were warm,neutral,cold or slightly cold in nature and had a sweet,bitter or pungent taste,and they mainly entered the lung,stomach,liver,and spleen meridians.The TCM drugs mainly had the following functions:tonifying deficiency;clearing heat;resolving phlegm,relieving cough,and relieving asthma;relieving exterior syndrome;regulating Qi.The hierarchical cluster analysis obtained 5 core drug combinations.Conclusion:Professor Zheng emphasizes“supporting the earth and reaching the wood”in the treatment of pulmonary nodules and often uses the methods of nourishing the lung and strengthening the spleen,soothing the liver and regulating Qi,and resolving phlegm and static blood,giving consideration to the protection of stomach Qi.As for medication,sweet drugs are often used to alleviate acute symptoms,with the characteristics of lifting with pungent herbs and descending with bitter herbs and applying both cold and warm drugs.

关 键 词：肺结节 中医药治疗 数据挖掘 郑卫琴 

分 类 号：R259.63[医药卫生—中西医结合]