药材粒度对冷浸法提取水冬瓜伤科止痛酊中黄芩苷和总固体物收率的影响  

Effect of particle size on baicalin content and total solid yield of Shuidonggua Painkilling Tincture prepared by cold soak

作　　者：杨元凤 罗玉玲 代欣 陈永敏 周训蓉 YANG Yuanfeng;LUO Yuling;DAI Xin;CHEN Yongmin;ZHOU Xunrong(Department of Pharmacy,The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550003,China;Traditional Chinese Medicine Research&Development Center,Guizhou University of Traditional Chinese Medicine,Guiyang 550003,China;Pharmaceutical Research and Development Center,Guizhou University of Traditional Chinese Medicine,Guiyang 550003,China)

机构地区：[1]贵州中医药大学第二附属医院药学部,贵州贵阳550003 [2]贵州中医药大学中药制剂研发中心,贵州贵阳550003 [3]贵州中医药大学制剂研究中心,贵州贵阳550003

出　　处：《贵州科学》2024年第1期1-4,共4页Guizhou Science

基　　金：贵州省中医药管理局中医药、民族医药科学技术课题研究资助项目(QZYY2013-74);贵州中医药大学院内科研项目(3040-04020001406)。

摘　　要：目的:考察不同药材粒度(最粗粉、粗粉、中粉、细粉)对冷浸法提取水冬瓜伤科止痛酊中黄芩苷和总固体物收率的影响。方法:采用高效液相色谱法测定黄芩苷,采用干燥失重法测定总固体物收率。以黄芩苷含量和总固体物收率为指标,优选制备水冬瓜伤科止痛酊最适宜的药材粒度。结果:最粗粉制得的酊剂中黄芩苷含量和总固体物收率均最高,分别是416.1μg/mL、18.08%。结论:药材粉碎粒度对黄芩苷含量和总固体物收率均有影响。We studied the effect of different particle sizes(the coarsest,coarse,medium and fine)on the baicalin content and total solid yield of Shuidonggua Painkilling Tincture extracted by cold soak.Baicalin was determined by high performance liquid chromatography,and the total solid yield was measured by loss on drying method.The baicalin content and total solid yield were taken as indicators to optimize the particle size for the preparation of Shuidonggua Painkilling Tincture.The results showed that the baicalin content and total solid yield of the tincture prepared from the coarsest powder were the highest,reaching 416.1μg/mL and 18.08%,respectively.Different particle sizes have different effect on the baicalin content and total solid yield of Shuidonggua Painkilling Tincture.

关 键 词：水冬瓜伤科止痛酊 不同粉碎粒度 黄芩苷 总固体物收率 

分 类 号：R284.1[医药卫生—中药学]