他克莫司血药浓度对肾移植术后患者肝肾功能的影响  

Impact of Tacrolimus Blood Concentration on Liver and Kidney Function of Patients After Renal Transplantation

作　　者：郑阳[1] 王兆睿 刘旭华[2] 胡亚会 ZHENG Yang;WANG Zhaorui;LIU Xuhua;HU Yahui(Clinical Laboratory,Zhengzhou People's Hospital/The People's Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450053,China;Translational Medicine Research Center,Zhengzhou People's Hospital/The People's Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450053,China)

机构地区：[1]郑州人民医院/河南中医药大学人民医院检验科,河南郑州450053 [2]郑州人民医院/河南中医药大学人民医院转化医学研究中心,河南郑州450053

出　　处：《临床医学工程》2024年第2期153-154,共2页Clinical Medicine & Engineering

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210710)。

摘　　要：目的探讨他克莫司(FK506)血药浓度对肾移植术后患者肝肾功能的影响。方法回顾性分析2018年10月至2020年10月在我院行肾移植手术的80例患者的临床资料,根据FK506血药浓度梯度不同分为7组,比较各组的肝肾功能指标水平,分析肝肾功能指标与FK506血药浓度的相关性。结果不同FK506血药浓度患者的血清ALB、UREA、SCr、Cys C及eGFR水平比较,差异有统计学意义(P<0.05);不同FK506血药浓度患者的血清TBIL、AST、ALT水平比较,差异无统计学意义(P>0.05)。Spearman相关分析显示,UREA、SCr、Cys C水平与FK506血药浓度呈正相关(r>0.01,P<0.05),eGFR水平与FK506血药浓度呈负相关(r=-0.385,P<0.05)。结论FK506血药浓度对肾移植术后患者肝功能指标的影响较小,但血药浓度过高可引起肾毒性反应。Objective To explore the impact of blood concentration of tacrolimus(FK506)on liver and kidney function of patients after renal transplantation.Methods The clinical data of 80 patients with renal transplantation in our hospital from October 2018 to October2020 were retrospectively analyzed and were divided into 7 groups according to the different blood concentration gradients of FK506.The levels of liver and kidney function indicators of each group were compared,and the correlations of liver and kidney function indicators with FK506 blood concentration were analyzed.Results Significant difference showed in serum ALB,UREA,SCr,Cys C and eGFR levels among patients with different FK506 blood concentrations(P<0.05);No significant difference was found in serum TBIL,AST and ALT levels among patients with different FK506 blood concentrations(P>0.05).Spearman correlation analysis showed that the levels of UREA,SCr and Cys C were positively correlated with the FK506 blood concentration(r>0.01,P<0.05),and the level of eGFR was negatively correlated with FK506 blood concentration(r=-0.385,P<0.05).Conclusions The blood concentration of FK506 has small impact on the liver function indicators of patients after renal transplantation;However,high blood concentration will cause nephrotoxicity.

关 键 词：肾移植 他克莫司 血药浓度 肝肾功能 

分 类 号：R617[医药卫生—外科学]