海藻酸钠载药口腔速溶膜的制备及性能研究  

Preparation and Performance Study of Sodium Alginate Loaded Oral Instant Film

作　　者：欧阳建梅 林艳霞 OUYANG Jianmei;LIN Yanxia(Shenzhen Bay Laboratory,Shenzhen,Guangdong 518000)

机构地区：[1]深圳湾实验室,广东深圳518000

出　　处：《化工生产与技术》2024年第1期7-10,15,I0002,共6页Chemical Production and Technology

摘　　要：针对当前药物突释、利用率低和持续释放等问题,以海藻酸钠(SA)和羟丙甲基纤维素(HPMC)为成膜剂,采用流延成膜的方法制备了海藻酸钠口腔速溶膜,对其化学结构、透光性和水溶性进行了分析,得到最佳的SA和HPMC的成膜比例,在此基础上,负载盐酸苄达明(BH)制备海藻酸钠载药口腔速溶膜。结果表明,最佳成膜比例为w(SA):w(HPMC)=1:2;另外,当BH负载量为30%时,海藻酸钠载药口腔速溶膜力学性能最好,当负载量为40%时,其包封率和载药效率最佳,经济成本更好。In response to the current issues of sudden drug release,low drug utilization,and sustained drug release,sodium alginate(SA)and hydroxypropyl methyl cellulose(HPMC)were used as film forming agents,and sodium alginate oral instant film was prepared by casting film forming method.The chemical structure,transparency,and water solubility of the films were analyzed,and the optimal film-forming ratio of SA and HPMC was obtained,and the preparation of sodium alginate loaded oral instant film with benzdamine hydrochloride(BH).The results showed that the optimal film-forming agent ratio was w(SA)∶w(HPMC)=1∶2.In addition,when the BH loading capacity was 30%,the mechanical properties of sodium alginate loaded oral instant film were the best.When the loading capacity is 40%,its encapsulation efficiency and drug loading efficiency were the best,and the economic cost was better.

关 键 词：海藻酸钠 口腔速溶膜 羟丙甲基纤维素 载药 

分 类 号：TQ320.722[化学工程—合成树脂塑料工业]