基于Box-Behnken响应面法优化白芍总苷脂质体凝胶的制备工艺  

Optimization of the Process for Preparing Liposome Gel of TGP Based on the Box-Behnken Response Surface Method XIA Qingyao

作　　者：夏清瑶 魏新尧 张爱民 刘成琳 WEI Xinyao;ZHANG Aimin;LIU Chenglin(Tonghua Normal University,Tonghua 134002,China)

机构地区：[1]通化师范学院,吉林通化134002

出　　处：《中国民族民间医药》2024年第2期41-45,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：通化师范学院非师范专业学生创新训练项目(CS2022144);2022年吉林省大学生创新创业训练计划项目(S202210202064)。

摘　　要：目的:优化白芍总苷脂质体凝胶的制备工艺。方法:以卡波姆用量、甘油用量、三乙醇胺用量为考察因素,均匀度、透明度、流动性为质量评价标准,采用Box-Behnken响应面法优化白芍总苷脂质体凝胶的制备工艺。结果:白芍总苷脂质体凝胶最佳制备工艺的卡波姆用量为2 g,甘油用量为90 g,三乙醇胺用量为30 g。结论:优化后的白芍总苷脂质体凝胶制备工艺制备出的白芍总苷脂质体凝胶外观均匀、透明度高、流动性好。优化后的白芍总苷脂质体凝胶制备工艺稳定可行,可以代替现有的传统制备工艺,应用于临床治疗。Objective Optimize the process for preparing liposome gel of TGP.Methods With the dosage of carbomer,glycerol and triethanolamine as the investigation factors,and the evenness,transparency and fluidity as the quality evaluation criteria,the Box-Behnken response surface method was used to optimize the process for preparing liposome gel of TGP.Results The dosage of carbomer was 2g,glycerol was 90g and triethanolamine was 30 g.Conclusion Liposome gel of TGP prepared by the optimized liposome gel of TGP preparation process has uniform appearance,high transparency and good fluidity.Therefore,the optimized process of liposome gel of TGP preparation is stable and feasible,and can replace the existing traditional preparation process for clinical treatment.

关 键 词：白芍总苷(TGP) 脂质体凝胶 Box-Behnken响应面法 制备技术 

分 类 号：R282.6[医药卫生—中药学]