三黄膏质量标准提升研究  

Study on the Improving the Quality Standard of Sanhuang Plaster

作　　者：王宝才[1] 李俊江[1] 李荣焜 杨小源[1] 徐志伟[1] WANG Baocai;LI Junjiang;LI Rongkun;YANG Xiaoyuan;XU Zhiwei(Gansu Provincial Hospital of TCM,Lanzhou 730050,China;Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃省中医院,甘肃兰州730050 [2]甘肃中医药大学,甘肃兰州730000

出　　处：《中国民族民间医药》2024年第1期51-54,共4页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：白银市科技计划项目(编号:2021-2-25Y)。

摘　　要：目的:提升三黄膏的质量标准。方法:制备三黄膏,进行性状观察和粒度检查,采用薄层色谱法对该制剂中的黄连药材进行定性鉴别,采用高效液相色谱法测定该制剂中的小檗碱、表小檗碱、黄连碱、巴马汀含量并规定其总含量限度。结果:本研究所制得的三黄膏为黄色至棕黄色的软膏;粒度检查符合相关规定;建立的薄层色谱法专属性强,可准确鉴别黄连药材;小檗碱、表小檗碱、黄连碱、巴马汀的平均总含量为4.01 mg/g,其含量限度不得少于3.21 mg/g。结论:本研究建立的三黄膏质量标准稳定、可行,可有效控制该制剂的质量。Objective Improving the Quality Standard of Sanhuang plaster.Method Sanhuang plaster were prepared and investigated in terms of property,granularity.Coptidis Rhizoma、Scutellariae radix was identified qualitatively by thin layer chromatography(TLC)method.High performance liquid chromatography method was used to determine the content of Berberine,epiberberine,berberine,palmatine and set the limit of total content.Result Sanhuang plaster prepared in this study were yellow to tan plaster;the granularity were in line with relevant regulations;the established TLC method possessed strong specificity and could accurately identify COPTIDIS RHIZOMA and SCUTELLARIAE RADIX.The average of total content of 4 alkaloids was 4.01 mg/g,and itscontent limit would not be less than 3.21 mg/g.Conclusion The quality standard of Sanhuang plaster established in this study is reliable,stable and feasible,which can effectively control the quality of the preparation.

关 键 词：三黄膏 质量标准 黄连 生物碱 黄芩 

分 类 号：R282.6[医药卫生—中药学]