基于加权TOPSIS法的氨甲环酸氯化钠注射液药物利用评价  

Drug use evaluation of tranexamic acid and sodium chloride injection based on weighted TOPSIS method

作　　者：李美娟 刘秀梅 李雷[3] 刘建萍[1] 刘利勤 向倩[4] 张进华 李青[1] Mei-Juan LI;Xiu-Mei LIU;Lei LI;Jian-Ping LIU;Li-Qin LIU;Qian XIANG;Jin-Hua ZHANG;Qing LI(Department of Pharmacy,First Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Pharmacy,The Fifth Clinical Medical College of Henan University of Chinese Medicine(Zhengzhou People's Hospital),Zhengzhou 450003,China;Department of Oncology and Vascular Intervention,First Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Pharmacy,Peking University First Hospital,Beijing 100034,China;Department of Pharmacy,Fujian Maternity and Child Health Care Hospital,Fuzhou 350001,China)

机构地区：[1]山西医科大学第一医院药学部,太原030001 [2]河南中医药大学第五临床医学院(郑州人民医院)药学部,郑州450003 [3]山西医科大学第一医院肿瘤与血管介入科,太原030001 [4]北京大学第一医院药学部,北京100034 [5]福建省妇幼保健院药剂科,福州350001

出　　处：《药物流行病学杂志》2023年第12期1321-1330,共10页Chinese Journal of Pharmacoepidemiology

摘　　要：目的建立氨甲环酸氯化钠注射液药物利用评价(DUE)标准,为临床合理用药提供依据。方法以药品说明书为基础,参照相关指南及文献,制定DUE标准细则,采用加权优劣解距离法(TOPSIS)对山西医科大学第一医院2022年2—8月出院病历进行合理性评价。结果171份病历中,用药方案与最优方案接近程度(C_(i))≥0.8(合理)的有66例,占38.60%;C_(i)介于0.6~0.8(基本合理)的73例,占42.69%;C_(i)<0.6(不合理)的32例,占18.71%。不合理用药主要表现在不良反应监护、给药剂量、适应证等方面。结论采用加权TOPSIS法对氨甲环酸氯化钠注射液进行合理性评价,其评价结果更加直观、方便。Objective To establish the rules of drug use evaluation(DUE)of tranexamic acid and sodium chloride injection,and to provide a basis for clinical rational drug use.Methods Based on the drug instruction and referring to relevant guidelines and literature,the DUE criteria were established,and the weighted TOPSIS method was used to evaluate the rationality of medical records discharged from the First Hospital of Shanxi Medical University from February to August 2022.Results Among the 171 cases of medication regimen,there are were 66 cases(38.60%)close to the optimal regimen(C_(i)≥0.8)(reasonable);C_(i)was between 0.6 and 0.8(basically reasonable)in 73 cases(42.69%);and C_(i)<0.6(unreasonable)in 32 cases(18.71%).The unreasonable phenomenon mainly appeared in adverse reaction monitoring,medication administered,indications and so on.Conclusion The weighted TOPSIS method is used to evaluate the rationality of tranexamic acid and sodium chloride injection,and its evaluation results are more intuitive and convenient.

关 键 词：氨甲环酸氯化钠注射液 加权优劣解距离法 药物利用评价 

分 类 号：R969[医药卫生—药理学]