基于趋避冲突行为的精神药理学研究进展  

Research progress in psychopharmacology based on approach-avoidance conflict behavior

作　　者：张志博 贾靖仪 文睿婷[2] 曾令高 梁建辉[1] ZHANG Zhibo;JIA Jingyi;WEN Ruiting;ZENG Linggao;LIANG Jianhui(Department of Molecular and Cellular Pharmacology,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China;Department of Pharmacy,Peking University People′s Hospital,Beijing 100044,China;NMPA Key Laboratory of Quality Monitoring of Anaesthetic and Psychotropic Substances,Chongqing Institute for Food and Drug Control,Chongqing 401121,China)

机构地区：[1]北京大学药学院分子与细胞药理学系,北京100191 [2]北京大学人民医院药学部,北京100044 [3]重庆市食品药品检验检测研究院,国家药品监督管理局麻醉精神药品质量监测重点实验室,重庆401121

出　　处：《中国药理学与毒理学杂志》2024年第2期144-152,共9页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(82173799)。

摘　　要：趋避冲突(AAC)是个体在面对相互矛盾的趋近或回避的想法时所发生的内部冲突,其反映了以过度趋近或过度回避为代表的焦虑、抑郁和成瘾等精神疾病的某些特征。皮质-边缘-纹状体系统的功能在神经层面影响着AAC发生时的行为选择,发展能够更好地体现AAC的相关行为学范式在评估药物疗效和指导新药开发方面意义重大。本文从精神药理学方面系统地总结了与AAC行为相关的神经机制、行为学范式及这些范式在行为药理学方面的应用,以期为诊断和治疗相关神经精神疾病提供新的视角和方法。Approach-avoidance conflict(AAC)refers to the internal conflict that individuals experi⁃ence when faced with conflicting approach or avoidance thoughts.It reveals some characteristics of mental disorders,such as anxiety,depression,and addiction represented by excessive tendencies of approach or avoidance.The function of the cortico-limbic-striatal system influences behavioral choices at the neural level during the onset of AAC,and the development of related behavioral paradigms that can better represent AAC behaviors is critical to evaluating the efficacy of drugs and guiding the development of new drugs.This paper summarizes the neural mechanisms,behavioral paradigms,and applications in behavioral pharmacology related to AAC behaviors from the perspective of psychopharmacology with a view to providing new perspectives and methods for the diagnosis and treatment of related neuro⁃psychiatric disorders.

关 键 词：趋避冲突 精神障碍 皮质-边缘-纹状体系统 梁氏情境应激箱 

分 类 号：R964[医药卫生—药理学] R395[医药卫生—药学]