One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide(NIPAM) in Water  

作　　者：Zi-Shan Li Jing Lyu Bei Qiu Ying-Hao Li Ruth Foley Ri-Jian Song Melissa Johnson Qiang Geng Wen-Xin Wang 

机构地区：[1]Institute of Precision Medicine(AUST-IPM),Anhui University of Science and Technology,Huainan 232001,China [2]Charles Institute of Dermatology,School of Medicine,University College Dublin,Dublin D04 V1W8,Ireland

出　　处：《Chinese Journal of Polymer Science》2024年第1期1-6,I0004,共7页高分子科学（英文版）

基　　金：financially supported by the Science Foundation Ireland (SFI) Frontiers for the Future 2019 call (No.19/FFP/6522);the National Natural Science Foundation of China (NSFC)(No.51873179);Irish Research Council (IRC) Government of Ireland Postdoctoral Fellowship (No.GOIPD/2022/209)。

摘　　要：Copper(0)-mediated reversible-deactivation radical polymerization(Cu(0)-mediated RDRP) of the water-soluble monomer Nisopropylacrylamide(NIPAM) has been challenging with the problems of high dispersity, poor control over the molecular weights(MWs) or complex or multi reaction steps, etc. In this work, we report the well-controlled polymerization of NIPAM in water via a facile one-pot and one-step Cu(0)-mediated RDRP. The results of this approach show that the key for kicking off the Cu(0)-mediated NIPAM RDRPs is to ensure sufficient Cu~I at the very beginning, and the key to achieve a well-controlled chain growth is to provide adequate deactivation strength during the polymerization process. For NIPAM, which has a high propagation rate constant, the deactivation control can be effectively enhanced by extra adding deactivator(i.e., Cu~II) to the system. Moreover, a low reaction temperature(4 ℃) is necessary in the controlled synthesis of higher MW poly(Nisopropylacrylamide)(PNIPAM) to avoid the compromise in control caused by the phase transition from its lower critical solution temperature(LCST). Through this new kinetically controlled strategy, PNIPAMs with well-defined structure, narrow molecular weight distributions(MWDs) and varied MWs were successfully achieved.

关 键 词：Cu(0)-mediated RDRP N-ISOPROPYLACRYLAMIDE Propagation DEACTIVATION Reaction parameters 

分 类 号：TQ225.261[化学工程—有机化工]