加味当归芍药散治疗慢性盆腔炎疗效的Meta分析  

Meta-analysis of efficacy of modified Danggui Shaoyao powder in the treatment of chronic pelvic inflammatory disease

作　　者：谭萌 申佩佩 叶金鑫 杨倪焱 吴艳华 TAN Meng;SHEN Peipei;YE Jinxin;YANG Niyan;WU Yanhua(School of Traditional Chinese Medicine,Ji′nan University,Guangzhou 510632,China;不详)

机构地区：[1]暨南大学中医学院,广州市510632 [2]广州市红十字会医院,510220

出　　处：《临床合理用药杂志》2024年第5期20-25,30,共7页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的评价加味当归芍药散治疗慢性盆腔炎的有效性。方法检索中国知网(CNKI)、万方数据知识服务平台、维普网数据库、PubMed、Embase及Cochrane Library中关于加味当归芍药散治疗慢性盆腔炎的临床随机对照试验(RCTs),检索时间为2010年1月—2021年12月。筛选出符合标准的文献进行数据提取和质量评价,最后运用RevMan 5.3软件进行Meta分析。结果共纳入9个RCTs,共计674例患者。结果显示:(1)试验组方案治疗慢性盆腔炎在总有效率、痊愈率、症状积分方面优于对照组(P<0.05);(2)试验组与对照组治疗慢性盆腔炎的不良反应发生率比较,差异无统计学意义(P=0.51);(3)试验组治疗慢性盆腔炎在提高IL-10、降低TNF-α水平方面优于对照组(P<0.05),但在提高IL-4水平方面,差异无统计学意义(P=0.33);(4)试验组治疗慢性盆腔炎在提高CD4^(+)、CD4^(+)/CD8^(+)与降低CD8^(+)方面优于对照组(P<0.05)。结论加味当归芍药散治疗慢性盆腔炎可以提高临床总有效率、痊愈率,降低症状积分,临床上可有效治疗慢性盆腔炎。基于分析结果,结论仍需要更多高质量、大样本的RCTs进行论证。Objective To review the effectiveness for chronic pelvic inflammation disease treated with modified Danggui Shaoyao powder.Methods The randomized controlled trials(RCTs)of chronic pelvic inflammation disease treated with modified Danggui Shaoyao powder were retrieved from CNKI,Wanfang databases,VIP,PubMed,Embase and Cochrane Library from January 2010 to December 2021.Then RCTs that meet the standards were screened for data extraction and quality evaluation,and finally the RevMan 5.3 software was used for Meta-analysis.Results A total of 9 RCTs(674 patients)were included.Results showed that:(1)The total effective rate,cure rate and symptom score of the treatment group in the treatment of chronic pelvic inflammatory disease were better than those in the control group with significant difference(P<0.05);(2)The difference of adverse reactions of the two groups compared in the treatment of chronic pelvic inflammatory disease was not statistically significant(P=0.51);(3)The treatment group treated chronic pelvic inflammatory disease were superior to the control group in increasing IL-10 and decreasing TNF-αlevels with significant difference(P<0.05),but in increasing IL-4 levels without significant difference(P=0.33);(4)Treatment of chronic pelvic inflammatory disease in the treatment group increased CD4^(+)and CD4^(+)/CD8^(+)levels and decreased the CD8^(+)level were superior to the control group,and the difference was statistically significant(P<0.05).Conclusion Modified Danggui Shaoyao powder in treating chronic pelvic inflammation disease can improve clinical efficacy and cure rate and reduce symptom scores.So it is clinically effective in the treatment of chronic pelvic inflammatory disease.Based on the analytic results,it needs more RCTs of high quality and large sample for the further verification.

关 键 词：慢性盆腔炎 当归芍药散 疗效 META分析 

分 类 号：R271.9[医药卫生—中西医结合]