清肺消炎丸联合布地奈德福莫特罗治疗老年COPD的效果及对炎性反应和肺功能的影响  

Effectiveness of Qingfei Xiaoyan pills combined with budesonide and formoterol fumarate in the treatment of elderly COPD patients and its effect on inflammatory response and pulmonary function

作　　者：张蕊 孙静 李春霞 李如 ZHANG Rui;SUN Jing;LI Chunxia;LI Ru(Department of Respiratory Medicine,XuanWu TCM Hospital Beijing,Beijing 100050,China;不详)

机构地区：[1]北京市宣武中医医院呼吸内科,100050 [2]河北省枣强县中医医院,053000

出　　处：《临床合理用药杂志》2024年第6期28-32,共5页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察清肺消炎丸联合布地奈德福莫特罗治疗老年慢性阻塞性肺疾病(COPD)的效果及对炎性反应和肺功能的影响。方法选取2020年7月—2022年7月北京市宣武中医医院收治的老年COPD患者100例,按照随机数字表法分为西药组和中西药结合组,各50例。西药组患者采用布地奈德福莫特罗吸入粉雾剂(Ⅰ)吸入治疗,中西药结合组患者则在西药组基础上联用清肺消炎丸治疗,2组患者治疗周期均为14 d。比较2组治疗前及治疗14 d后炎性指标[血清C反应蛋白(CRP)、白细胞计数(WBC)、中性粒细胞计数(N)]、血气指标[动脉血二氧化碳分压(PaCO_(2))、动脉血氧饱和度(SaO_(2))]、肺功能指标[第1秒用力呼气容积(FEV_(1))、FEV_(1)与用力肺活量比值(FEV_(1)/FVC)]、6 min步行试验(6MWT)评分、咳嗽症状积分表(CSS)评分、日排痰量及不良反应。结果中西药结合组患者治疗总有效率高于西药组(88.00%vs.70.00%,χ^(2)=4.882,P=0.027)。治疗14 d后,2组患者血清CRP水平、WBC、N、PaCO_(2)低于治疗前,SaO_(2)高于治疗前,且中西药结合组患者降低/升高幅度大于西药组(P<0.01);2组患者FEV_(1)、FEV_(1)/FVC及6MWT评分高于治疗前,且中西药结合组高于西药组(P<0.01);2组患者CSS评分低于治疗前,日排痰量多于治疗前,且中西药结合组优于西药组(P<0.01)。中西药结合组头晕目眩、消化道不适、皮疹总发生率低于西药组(8.00%vs.26.00%,χ^(2)=5.741,P=0.017)。结论清肺消炎丸联合布地奈德福莫特罗治疗能够显著减轻老年COPD患者机体炎性反应,提高肺通气及血氧循环效率,改善肺功能,减轻临床症状,且安全性较高。Objective To observe the effect of Qingfei Xiaoyan pills combined with budesonide and formoterol fumarate in the treatment of elderly COPD patients and its effect on inflammatory response and pulmonary function.Methods A total of 100 cases of elderly COPD patients admitted to XuanWu TCM Hospital Beijing from July 2020 to July 2022 were selected,and they were divided into the western medicine group and the TCM combination group according to the random number table method,each group with 50 cases.Patients in the western medicine group were treated with budesonide and formoterol fumarate powder for inhalation(Ⅰ),while patients in the TCM combination group were treated with Qingfei Xiaoyan pills on the basis of the western medicine group,and the treatment cycle of the two groups was 14 days.Comparison was made between the two groups in terms of the inflammatory indexes(serum CRP,WBC,N),blood gas indexes(PaCO_(2),SaO_(2)),pulmonary function indexes(FEV_(1),FEV_(1)/FVC),6MWT score,CSS score,daily sputum output before and after 14 days of treatment,and the adverse reactions of both groups were also compared.Results The total effective rate of patients in the TCM combination group was higher than that in the western medicine group(88.00%vs.70.00%,χ^(2)=4.882,P=0.027).After 14 days of treatment,serum CRP level,WBC,N,PaCO_(2)in the two groups were lower than those before treatment,SaO_(2)was higher than that before treatment,and the decrease/increase of indexes in the TCM combination group were greater than those in the western medicine group(P<0.01);FEV_(1),FEV_(1)/FVC and 6MWT score in the two groups were higher than those before treatment,and the TCM combination group were higher than those in the western medicine group(P<0.01);CSS score of patients in the two groups was lower than that before treatment,and the daily sputum output was more than that before treatment,and the TCM combination group were better than those of the western medicines group(P<0.01).The incidence of adverse reactions of dizziness,gastrointesti

关 键 词：慢性阻塞性肺疾病 老年人 清肺消炎丸 布地奈德福莫特罗 炎性因子 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]