早期肠内营养对肝胆胰恶性肿瘤术后化疗患者营养状况及免疫功能的影响  

Effects of Early Enteral Nutrition on Nutritional Status and Immune Function in Patients with Hepatobiliary and Pancreatic Malignancies Undergoing Postoperative Chemotherapy

作　　者：时明明[1] SHI Mingming(Shanxian Central Hospital of Heze City,Heze,Shandong Province,274300 China)

机构地区：[1]山东省菏泽市单县中心医院,山东菏泽274300

出　　处：《中外医疗》2023年第35期21-24,共4页China & Foreign Medical Treatment

摘　　要：目的探讨肝胆胰恶性肿瘤手术之后接受化疗者实施早期肠内营养干预的价值,以及对营养情况、免疫功能状况的改善结果。方法随机选取2018年3月—2020年3月山东省菏泽市单县中心医院收治的80例肝胆胰恶性肿瘤术后化疗患者为样本对象,按随机数表法分为观察组、对照组,每组40例,对照组进行肠外营养支持治疗,观察组进行早期肠内营养支持治疗,对两组营养状况、细胞免疫功能及体液免疫功能进行比较。结果干预1周后,观察组主观整体营养状况具体评估量表(Patient Generated Subjective Global Assessment,PG-SGA)评分与对照组相比更低,差异有统计学意义(P<0.05);观察组外周血T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))水平高于对照组,差异有统计学意义(P<0.05),观察组外周血T淋巴细胞亚群(CD8^(+))(25.63±2.53)%低于对照组,差异有统计学意义(t=3.258,P<0.05);干预1周后,观察组免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白M(immunoglobulin M,IgM)高于对照组,差异有统计学意义(P<0.05)。结论肝胆胰恶性肿瘤术后化疗患者采用早期肠内营养可有效改善营养状况,提高免疫功能。Objective To investigate the value of early enteral nutrition intervention in patients receiving chemotherapy after surgery for hepatobiliary and pancreatic malignancies,and to improve the nutritional status and immune function.Methods 80 patients with hepatobiliary and pancreatic malignancies undergoing postoperative chemotherapy treated in Shanxian Central Hospital of Heze City,Shandong Province from March 2018 to March 2020 were randomly selected as sample objects.Random number table method was used to divide them into observation group and control group,with 40 in each group.The control group received parenteral nutrition support treatment,and the observation group received early enteral nutrition support treatment.The nutritional status,cellular immune function and humoral immune function of the two groups were compared.Results After 1 week of intervention,the scores of the Patient Generated Subjective Global Assessment(PG-SGA)in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Peripheral blood T lymphocyte subsets(CD3^(+),CD4^(+),CD4^(+)/CD8^(+))in observation group were higher than those in control group,and the differences was statistically significant(P<0.05);and peripheral blood T lymphocyte subsets(CD8^(+))in observation group(25.63±2.53)%were lower than that in control group,and the difference was statistically significant(t=3.258,P<0.05).After 1 week of intervention,immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Early enteral nutrition can effectively improve the nutritional status and immune function of patients with hepatobiliary and pancreatic malignancies undergoing postoperative chemotherapy.

关 键 词：早期肠内营养 肝胆胰恶性肿瘤 化疗 营养状况 免疫功能 

分 类 号：R5[医药卫生—内科学]