硝苯地平联合硫酸镁治疗妊娠期高血压的综合效果评价  

Comprehensive Effect of Nifedipine Combined with Magnesium Sulfate in the Treatment of Hypertension during Pregnancy

作　　者：程丽珊 江瑾 吴静 CHENG Lishan;JIANG Jin;WU Jing(Department of Obstetrics and Gynecology,Nanping Second Hospital,Nanping,Fujian Province,354200 China)

机构地区：[1]南平市第二医院妇产科,福建南平354200

出　　处：《中外医疗》2023年第35期89-92,共4页China & Foreign Medical Treatment

摘　　要：目的探讨硝苯地平联合硫酸镁方案在妊娠期高血压患者中的应用效果。方法随机选取2020年2月—2023年2月南平市第二医院收治的妊娠期高血压患者70例,按照随机数表法分为参照组和研究组,每组35例。参照组应用硫酸镁注射液治疗,研究组采取硝苯地平联合硫酸镁方案。比较两组血流动力学指标、血压水平、肾功能水平、妊娠结局。结果治疗后,研究组红细胞比容、血黏度、阻力指数均低于参照组,差异有统计学意义(P<0.05)。研究组脐动脉舒张压血流峰速比值(1.71±0.28)低于参照组,差异有统计学意义(t=10.480,P<0.05)。治疗后,研究组收缩压、舒张压、24 h尿蛋白量、24 h尿肌酐量均比参照组低,差异有统计学意义(P<0.05)。研究组不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05)。结论硝苯地平、硫酸镁方案相结合,可促使妊娠期高血压人群的妊娠结局改善。此种方法还可调节血流动力学,对提高患者总体治疗效果具有重要价值。Objective To investigate the application effect of nifedipine combined with magnesium sulfate in hypertensive patients during pregnancy.Methods 70 cases of hypertensive patients in pregnancy admitted to the Second Hospital of Nanping City from February 2020 to February 2023 were randomly selected and divided into reference group and study group according to the random number table method,with 35 cases in each group.The reference group was treated with magnesium sulfate injection,and the study group adopted nifedipine combined with magnesium sulfate program.The hemodynamic indexes,blood pressure levels,renal function levels,and pregnancy outcomes of the two groups were compared.Results After treatment,the erythrocyte pressure product,blood viscosity and resistance index of the study group were lower than those of the reference group,and the difference was statistically significant(P<0.05).The peak velocity ratio of diastolic blood flow in umbilical artery of the study group(1.71±0.28)was lower than that of the reference group,and the differences were statistically significant(t=10.480,P<0.05).After treatment,the systolic blood pressure,diastolic blood pressure,24 h urine protein volume and 24 h urine creatinine volume were lower in the study group than in the reference group,and the differences were statistically significant(P<0.05).The incidence of adverse pregnancy outcomes was lower in the study group than in the reference group,and the difference was statistically significant(P<0.05).Conclusion The combination of nifedipine and magnesium sulfate can improve the pregnancy outcome of hypertensive patients during pregnancy.This method can also regulate the hemodynamics,which is of great value in improving the overall therapeutic effect of patients.

关 键 词：妊娠期高血压 硫酸镁 硝苯地平 联合用药 血流动力学指标 

分 类 号：R5[医药卫生—内科学]