卵圆孔未闭相关神经系统并发症发病机制及治疗研究进展  

Recent advance in pathogenesis and treatments of neurological complications related to patent foramen ovale

作　　者：汪傲雪 唐艺菡 桑睿琪 吴智勇[1] 阮永乐[1] Wang Aoxue;Tang Yihan;Sang Ruiqi;Wu Zhiyong;Ruan Yongle(Department of Cardiovascular Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院心血管外科,武汉430060

出　　处：《中华神经医学杂志》2023年第12期1282-1286,共5页Chinese Journal of Neuromedicine

基　　金：中国博士后科学基金(2017M620339)。

摘　　要：卵圆孔未闭是最常见的先天性心脏病,患者常伴有偏头痛、不明原因头晕等一系列神经系统症状,甚至会出现焦虑、抑郁症等精神症状。最新的研究结果显示,卵圆孔未闭的神经系统并发症发病机制包括反常栓塞假说、血管活性物质假说、脑血流调节受损以及基因遗传等,治疗方法主要包括药物治疗以及手术封堵卵圆孔。本文现围绕上述研究进展进行综述,以期为临床早期识别及诊治卵圆孔未闭相关神经系统并发症提供参考。Patent foramen ovale(PFO)is the most prevalent congenital heart disease,often accompanied by neurological symptoms as migraine,unexplained dizziness,and even anxiety and depression.Recent research findings indicate that the pathogenesis of neurological complications related to PFO involves abnormal embolism hypothesis,vasoactive substance hypothesis,impaired cerebral blood flow regulation and genetic inheritance.Treatments include primarily encompass pharmacological intervention and foramen ovale occlusion.This article summarizes the aforementioned research progress in order to provide clinical guidance for managing nervous system complications related to PFO.

关 键 词：卵圆孔未闭 偏头痛 隐源性脑卒中 抑郁症 阿尔茨海默病 

分 类 号：R541.1[医药卫生—心血管疾病] R747.9[医药卫生—内科学]