鼻腔内一氧化氮分布的实验及数值研究进展  

Research Progress of Experimental and Numerical Study on Nitric Oxide Distributions in Nasal Cavity

作　　者：于申[1] 王丹青 郭燕[2] 王吉喆[2] YU Shen;WANG Danqing;GUO Yan;WANG Jizhe(State Key Laboratory of Structural Analysis for Industrial Equipment,Dalian University of Technology,Dalian 116024,Liaoning,China;Department of Otorhinalaryngology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,Liaoning,China)

机构地区：[1]大连理工大学工业装备结构分析国家重点实验室,辽宁大连116024 [2]大连医科大学附属二院耳鼻咽喉科,辽宁大连116027

出　　处：《医用生物力学》2023年第6期1248-1253,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(12172082)。

摘　　要：一氧化氮(nitric oxide,NO)在鼻腔内参与抗菌、抗病毒、促进鼻黏膜纤毛摆动、调节鼻黏膜血管扩张等多种生理功能。NO浓度异常会导致多种鼻腔疾病的发生,已成为临床常规检测气道炎症的生物学指标。随着医学与力学等领域的深入交叉,运用数值研究方法,与传统的实验方法相结合,对鼻腔内NO浓度分布进行分析,可量化鼻腔内各处NO浓度,获得鼻腔内NO的分布规律,辅助相关鼻腔疾病的临床诊疗,有助于推动精准医疗的发展。本文对鼻腔内NO浓度分布实验研究及数值研究的进展进行综述,并对未来研究方向进行展望。In the nasal cavity,nitric oxide(NO)is involved in many physiological functions,including antibacterial and antiviral activity,promotion of nasal mucociliary clearance,and regulation of blood vessel expansion in the nasal mucosa.The abnormal concentration of NO will lead to the occurrence of various nasal diseases,and NO concentration has become a biological indicator for routine clinical detection of airway inflammation.With the in-depth intersection of medicine and mechanics and other fields,the use of numerical research methods,combined with traditional experimental methods,the distribution of NO concentration in nasal cavity can be analyzed,and NO concentration in various parts of nasal cavity can be quantified,so as to obtain the distribution patterns of NO in nasal cavity,assist the clinical diagnosis and treatment of related nasal diseases,and help promote the development of precision medicine.In this review,the progress of experimental and numerical studies on the distribution of NO concentration in nasal cavity was summarized,and the future research direction was prospected.

关 键 词：鼻腔 一氧化氮分布 浓度测试 数值模拟 

分 类 号：R318.01[医药卫生—生物医学工程]